TY - JOUR
T1 - Proteomic Analysis of the Human Anterior Pituitary Gland
AU - Yelamanchi, Soujanya D.
AU - Tyagi, Ankur
AU - Mohanty, Varshasnata
AU - Dutta, Pinaki
AU - Korbonits, Márta
AU - Chavan, Sandip
AU - Advani, Jayshree
AU - Madugundu, Anil K.
AU - Dey, Gourav
AU - Datta, Keshava K.
AU - Rajyalakshmi, M.
AU - Sahasrabuddhe, Nandini A.
AU - Chaturvedi, Abhishek
AU - Kumar, Amit
AU - Das, Apabrita Ayan
AU - Ghosh, Dhiman
AU - Jogdand, Gajendra M.
AU - Nair, Haritha H.
AU - Saini, Keshav
AU - Panchal, Manoj
AU - Sarvaiya, Mansi Ashwinsinh
AU - Mohanraj, Soundappan S.
AU - Sengupta, Nabonita
AU - Saxena, Priti
AU - Subramani, Pradeep Annamalai
AU - Kumar, Pradeep
AU - Akkali, Rakhil
AU - Reshma, Saraswatipura Vishwabrahmachar
AU - Santhosh, Ramachandran Sarojini
AU - Rastogi, Sangita
AU - Kumar, Sudarshan
AU - Ghosh, Susanta Kumar
AU - Irlapati, Vamshi Krishna
AU - Srinivasan, Anand
AU - Radotra, Bishan Das
AU - Mathur, Premendu P.
AU - Wong, G. William
AU - Satishchandra, Parthasarathy
AU - Chatterjee, Aditi
AU - Gowda, Harsha
AU - Bhansali, Anil
AU - Pandey, Akhilesh
AU - Shankar, Susarla K.
AU - Mahadevan, Anita
AU - Prasad, T. S.Keshava
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.
AB - The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.
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U2 - 10.1089/omi.2018.0160
DO - 10.1089/omi.2018.0160
M3 - Article
C2 - 30571610
AN - SCOPUS:85058925838
VL - 22
SP - 759
EP - 769
JO - OMICS A Journal of Integrative Biology
JF - OMICS A Journal of Integrative Biology
SN - 1536-2310
IS - 12
ER -