Proteomic Analysis of the Human Anterior Pituitary Gland

Soujanya D. Yelamanchi, Ankur Tyagi, Varshasnata Mohanty, Pinaki Dutta, Márta Korbonits, Sandip Chavan, Jayshree Advani, Anil K. Madugundu, Gourav Dey, Keshava K. Datta, M. Rajyalakshmi, Nandini A. Sahasrabuddhe, Abhishek Chaturvedi, Amit Kumar, Apabrita Ayan Das, Dhiman Ghosh, Gajendra M. Jogdand, Haritha H. Nair, Keshav Saini, Manoj Panchal & 25 others Mansi Ashwinsinh Sarvaiya, Soundappan S. Mohanraj, Nabonita Sengupta, Priti Saxena, Pradeep Annamalai Subramani, Pradeep Kumar, Rakhil Akkali, Saraswatipura Vishwabrahmachar Reshma, Ramachandran Sarojini Santhosh, Sangita Rastogi, Sudarshan Kumar, Susanta Kumar Ghosh, Vamshi Krishna Irlapati, Anand Srinivasan, Bishan Das Radotra, Premendu P. Mathur, G. William Wong, Parthasarathy Satishchandra, Aditi Chatterjee, Harsha Gowda, Anil Bhansali, Akhilesh Pandey, Susarla K. Shankar, Anita Mahadevan, T. S.Keshava Prasad

Research output: Contribution to journalArticle

Abstract

The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

Original languageEnglish
Pages (from-to)759-769
Number of pages11
JournalOMICS A Journal of Integrative Biology
Volume22
Issue number12
DOIs
Publication statusPublished - 01-01-2018

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Anterior Pituitary Gland
Proteomics
Proteins
Pituitary Diseases
Pituitary Hormones
Fourier Analysis
Pituitary Gland
Proteome
Hypothalamus
Mass spectrometry
Biomedical Research
Large scale systems
Mass Spectrometry
Fourier transforms
Throughput
Health
Hormones
Research

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Yelamanchi, S. D., Tyagi, A., Mohanty, V., Dutta, P., Korbonits, M., Chavan, S., ... Prasad, T. S. K. (2018). Proteomic Analysis of the Human Anterior Pituitary Gland. OMICS A Journal of Integrative Biology, 22(12), 759-769. https://doi.org/10.1089/omi.2018.0160
Yelamanchi, Soujanya D. ; Tyagi, Ankur ; Mohanty, Varshasnata ; Dutta, Pinaki ; Korbonits, Márta ; Chavan, Sandip ; Advani, Jayshree ; Madugundu, Anil K. ; Dey, Gourav ; Datta, Keshava K. ; Rajyalakshmi, M. ; Sahasrabuddhe, Nandini A. ; Chaturvedi, Abhishek ; Kumar, Amit ; Das, Apabrita Ayan ; Ghosh, Dhiman ; Jogdand, Gajendra M. ; Nair, Haritha H. ; Saini, Keshav ; Panchal, Manoj ; Sarvaiya, Mansi Ashwinsinh ; Mohanraj, Soundappan S. ; Sengupta, Nabonita ; Saxena, Priti ; Subramani, Pradeep Annamalai ; Kumar, Pradeep ; Akkali, Rakhil ; Reshma, Saraswatipura Vishwabrahmachar ; Santhosh, Ramachandran Sarojini ; Rastogi, Sangita ; Kumar, Sudarshan ; Ghosh, Susanta Kumar ; Irlapati, Vamshi Krishna ; Srinivasan, Anand ; Radotra, Bishan Das ; Mathur, Premendu P. ; Wong, G. William ; Satishchandra, Parthasarathy ; Chatterjee, Aditi ; Gowda, Harsha ; Bhansali, Anil ; Pandey, Akhilesh ; Shankar, Susarla K. ; Mahadevan, Anita ; Prasad, T. S.Keshava. / Proteomic Analysis of the Human Anterior Pituitary Gland. In: OMICS A Journal of Integrative Biology. 2018 ; Vol. 22, No. 12. pp. 759-769.
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Yelamanchi, SD, Tyagi, A, Mohanty, V, Dutta, P, Korbonits, M, Chavan, S, Advani, J, Madugundu, AK, Dey, G, Datta, KK, Rajyalakshmi, M, Sahasrabuddhe, NA, Chaturvedi, A, Kumar, A, Das, AA, Ghosh, D, Jogdand, GM, Nair, HH, Saini, K, Panchal, M, Sarvaiya, MA, Mohanraj, SS, Sengupta, N, Saxena, P, Subramani, PA, Kumar, P, Akkali, R, Reshma, SV, Santhosh, RS, Rastogi, S, Kumar, S, Ghosh, SK, Irlapati, VK, Srinivasan, A, Radotra, BD, Mathur, PP, Wong, GW, Satishchandra, P, Chatterjee, A, Gowda, H, Bhansali, A, Pandey, A, Shankar, SK, Mahadevan, A & Prasad, TSK 2018, 'Proteomic Analysis of the Human Anterior Pituitary Gland', OMICS A Journal of Integrative Biology, vol. 22, no. 12, pp. 759-769. https://doi.org/10.1089/omi.2018.0160

Proteomic Analysis of the Human Anterior Pituitary Gland. / Yelamanchi, Soujanya D.; Tyagi, Ankur; Mohanty, Varshasnata; Dutta, Pinaki; Korbonits, Márta; Chavan, Sandip; Advani, Jayshree; Madugundu, Anil K.; Dey, Gourav; Datta, Keshava K.; Rajyalakshmi, M.; Sahasrabuddhe, Nandini A.; Chaturvedi, Abhishek; Kumar, Amit; Das, Apabrita Ayan; Ghosh, Dhiman; Jogdand, Gajendra M.; Nair, Haritha H.; Saini, Keshav; Panchal, Manoj; Sarvaiya, Mansi Ashwinsinh; Mohanraj, Soundappan S.; Sengupta, Nabonita; Saxena, Priti; Subramani, Pradeep Annamalai; Kumar, Pradeep; Akkali, Rakhil; Reshma, Saraswatipura Vishwabrahmachar; Santhosh, Ramachandran Sarojini; Rastogi, Sangita; Kumar, Sudarshan; Ghosh, Susanta Kumar; Irlapati, Vamshi Krishna; Srinivasan, Anand; Radotra, Bishan Das; Mathur, Premendu P.; Wong, G. William; Satishchandra, Parthasarathy; Chatterjee, Aditi; Gowda, Harsha; Bhansali, Anil; Pandey, Akhilesh; Shankar, Susarla K.; Mahadevan, Anita; Prasad, T. S.Keshava.

In: OMICS A Journal of Integrative Biology, Vol. 22, No. 12, 01.01.2018, p. 759-769.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Proteomic Analysis of the Human Anterior Pituitary Gland

AU - Yelamanchi, Soujanya D.

AU - Tyagi, Ankur

AU - Mohanty, Varshasnata

AU - Dutta, Pinaki

AU - Korbonits, Márta

AU - Chavan, Sandip

AU - Advani, Jayshree

AU - Madugundu, Anil K.

AU - Dey, Gourav

AU - Datta, Keshava K.

AU - Rajyalakshmi, M.

AU - Sahasrabuddhe, Nandini A.

AU - Chaturvedi, Abhishek

AU - Kumar, Amit

AU - Das, Apabrita Ayan

AU - Ghosh, Dhiman

AU - Jogdand, Gajendra M.

AU - Nair, Haritha H.

AU - Saini, Keshav

AU - Panchal, Manoj

AU - Sarvaiya, Mansi Ashwinsinh

AU - Mohanraj, Soundappan S.

AU - Sengupta, Nabonita

AU - Saxena, Priti

AU - Subramani, Pradeep Annamalai

AU - Kumar, Pradeep

AU - Akkali, Rakhil

AU - Reshma, Saraswatipura Vishwabrahmachar

AU - Santhosh, Ramachandran Sarojini

AU - Rastogi, Sangita

AU - Kumar, Sudarshan

AU - Ghosh, Susanta Kumar

AU - Irlapati, Vamshi Krishna

AU - Srinivasan, Anand

AU - Radotra, Bishan Das

AU - Mathur, Premendu P.

AU - Wong, G. William

AU - Satishchandra, Parthasarathy

AU - Chatterjee, Aditi

AU - Gowda, Harsha

AU - Bhansali, Anil

AU - Pandey, Akhilesh

AU - Shankar, Susarla K.

AU - Mahadevan, Anita

AU - Prasad, T. S.Keshava

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic profiling of human anterior pituitary gland (adenohypophysis) using high-resolution Fourier transform mass spectrometry. A total of 2164 proteins were identified in this study, of which 105 proteins were identified for the first time compared with high-throughput proteomic-based studies from human pituitary glands. In addition, we identified 480 proteins with secretory potential and 187 N-terminally acetylated proteins. These are the first region-specific data that could serve as a vital resource for further investigations on the physiological role of the human anterior pituitary glands and the proteins secreted by them. We anticipate that the identification of previously unknown proteins in the present study will accelerate biomedical research to decipher their role in functioning of the human anterior pituitary gland and associated human diseases.

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Yelamanchi SD, Tyagi A, Mohanty V, Dutta P, Korbonits M, Chavan S et al. Proteomic Analysis of the Human Anterior Pituitary Gland. OMICS A Journal of Integrative Biology. 2018 Jan 1;22(12):759-769. https://doi.org/10.1089/omi.2018.0160