Pulmonary nocardiosis due to Nocardia farcinica in a renal transplant recipient.

K. Gowrinath, Waqas Wahid Baig, Attur Ravindra Prabhu, Kiran Chawla, Indira Bairy

Research output: Contribution to journalArticle

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Abstract

Nocardia farcinica is an infrequent cause of nocardiosis among the renal transplant recipients and it has not been reported so far from India. We report a case of pulmonary nocardiosis due to N. farcinica in a 32-year-old woman with hypothyroidism and post-renal transplant status, currently on immunosuppressive therapy (prednisolone, azathioprine and tacrolimus). The N. farcinica isolate was susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), linezolid, imipenem, gentamicin but resistant to ceftriaxone, ciprofloxacin, tobramycin, erythromycin, amoxycillin-clavulanic acid and tetracycline. Treatment with TMP-SMZ and linezolid resulted in marked clinico-radiological improvement but after two weeks both of the drugs had to be stopped due to severe pancytopenia as adverse effect of their use. Currently, the patient is on imipenem and remains stable after four weeks of treatment. In N. farcinica infections, multi antibiotic resistance and toxicity of some specific drugs enhances the risk of therapeutic failure in renal transplant recipients.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
JournalThe Indian journal of chest diseases & allied sciences
Volume51
Issue number4
Publication statusPublished - 01-10-2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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