Pulmonary nocardiosis due to Nocardia farcinica in a renal transplant recipient.

K. Gowrinath, Waqas Wahid Baig, Attur Ravindra Prabhu, Kiran Chawla, Indira Bairy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Nocardia farcinica is an infrequent cause of nocardiosis among the renal transplant recipients and it has not been reported so far from India. We report a case of pulmonary nocardiosis due to N. farcinica in a 32-year-old woman with hypothyroidism and post-renal transplant status, currently on immunosuppressive therapy (prednisolone, azathioprine and tacrolimus). The N. farcinica isolate was susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), linezolid, imipenem, gentamicin but resistant to ceftriaxone, ciprofloxacin, tobramycin, erythromycin, amoxycillin-clavulanic acid and tetracycline. Treatment with TMP-SMZ and linezolid resulted in marked clinico-radiological improvement but after two weeks both of the drugs had to be stopped due to severe pancytopenia as adverse effect of their use. Currently, the patient is on imipenem and remains stable after four weeks of treatment. In N. farcinica infections, multi antibiotic resistance and toxicity of some specific drugs enhances the risk of therapeutic failure in renal transplant recipients.

Original languageEnglish
Pages (from-to)237-239
Number of pages3
JournalThe Indian journal of chest diseases & allied sciences
Volume51
Issue number4
Publication statusPublished - 01-10-2009

Fingerprint

Nocardia Infections
Nocardia
Linezolid
Kidney
Imipenem
Sulfamethoxazole Drug Combination Trimethoprim
Amoxicillin-Potassium Clavulanate Combination
Pancytopenia
Tobramycin
Ceftriaxone
Azathioprine
Tacrolimus
Erythromycin
Therapeutics
Immunosuppressive Agents
Ciprofloxacin
Microbial Drug Resistance
Prednisolone
Hypothyroidism
Gentamicins

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

@article{32be0735cc6c4fbcb30fd529aa642a7d,
title = "Pulmonary nocardiosis due to Nocardia farcinica in a renal transplant recipient.",
abstract = "Nocardia farcinica is an infrequent cause of nocardiosis among the renal transplant recipients and it has not been reported so far from India. We report a case of pulmonary nocardiosis due to N. farcinica in a 32-year-old woman with hypothyroidism and post-renal transplant status, currently on immunosuppressive therapy (prednisolone, azathioprine and tacrolimus). The N. farcinica isolate was susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), linezolid, imipenem, gentamicin but resistant to ceftriaxone, ciprofloxacin, tobramycin, erythromycin, amoxycillin-clavulanic acid and tetracycline. Treatment with TMP-SMZ and linezolid resulted in marked clinico-radiological improvement but after two weeks both of the drugs had to be stopped due to severe pancytopenia as adverse effect of their use. Currently, the patient is on imipenem and remains stable after four weeks of treatment. In N. farcinica infections, multi antibiotic resistance and toxicity of some specific drugs enhances the risk of therapeutic failure in renal transplant recipients.",
author = "K. Gowrinath and Baig, {Waqas Wahid} and Prabhu, {Attur Ravindra} and Kiran Chawla and Indira Bairy",
year = "2009",
month = "10",
day = "1",
language = "English",
volume = "51",
pages = "237--239",
journal = "The Indian journal of chest diseases",
issn = "0377-9343",
publisher = "University of Delhi",
number = "4",

}

Pulmonary nocardiosis due to Nocardia farcinica in a renal transplant recipient. / Gowrinath, K.; Baig, Waqas Wahid; Prabhu, Attur Ravindra; Chawla, Kiran; Bairy, Indira.

In: The Indian journal of chest diseases & allied sciences, Vol. 51, No. 4, 01.10.2009, p. 237-239.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pulmonary nocardiosis due to Nocardia farcinica in a renal transplant recipient.

AU - Gowrinath, K.

AU - Baig, Waqas Wahid

AU - Prabhu, Attur Ravindra

AU - Chawla, Kiran

AU - Bairy, Indira

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Nocardia farcinica is an infrequent cause of nocardiosis among the renal transplant recipients and it has not been reported so far from India. We report a case of pulmonary nocardiosis due to N. farcinica in a 32-year-old woman with hypothyroidism and post-renal transplant status, currently on immunosuppressive therapy (prednisolone, azathioprine and tacrolimus). The N. farcinica isolate was susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), linezolid, imipenem, gentamicin but resistant to ceftriaxone, ciprofloxacin, tobramycin, erythromycin, amoxycillin-clavulanic acid and tetracycline. Treatment with TMP-SMZ and linezolid resulted in marked clinico-radiological improvement but after two weeks both of the drugs had to be stopped due to severe pancytopenia as adverse effect of their use. Currently, the patient is on imipenem and remains stable after four weeks of treatment. In N. farcinica infections, multi antibiotic resistance and toxicity of some specific drugs enhances the risk of therapeutic failure in renal transplant recipients.

AB - Nocardia farcinica is an infrequent cause of nocardiosis among the renal transplant recipients and it has not been reported so far from India. We report a case of pulmonary nocardiosis due to N. farcinica in a 32-year-old woman with hypothyroidism and post-renal transplant status, currently on immunosuppressive therapy (prednisolone, azathioprine and tacrolimus). The N. farcinica isolate was susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), linezolid, imipenem, gentamicin but resistant to ceftriaxone, ciprofloxacin, tobramycin, erythromycin, amoxycillin-clavulanic acid and tetracycline. Treatment with TMP-SMZ and linezolid resulted in marked clinico-radiological improvement but after two weeks both of the drugs had to be stopped due to severe pancytopenia as adverse effect of their use. Currently, the patient is on imipenem and remains stable after four weeks of treatment. In N. farcinica infections, multi antibiotic resistance and toxicity of some specific drugs enhances the risk of therapeutic failure in renal transplant recipients.

UR - http://www.scopus.com/inward/record.url?scp=77449103537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77449103537&partnerID=8YFLogxK

M3 - Article

VL - 51

SP - 237

EP - 239

JO - The Indian journal of chest diseases

JF - The Indian journal of chest diseases

SN - 0377-9343

IS - 4

ER -