Non immediate allergic reactions (NIRs) to drugs, due to specific immunologic mechanisms, can be induced by many commercially available drugs Maculopapular exanthema (MPE) is the one among the commonest manifestation following NIRs. Cytokines are known to play a dominant role in causing MPE. T helper 1 (Th1) cytokines and CD4 (+) T cells play a very pivotal role in the pathogenesis of this condition. As a part of pharmaovigilance program we hereby report a case of Maculopapular rash induced by pyrazinamide in a patient treated for pulmonary tuberculosis. The causality, severity, and preventability assessment of the adverse drug reaction was done to establish a causal relationship.
|Number of pages||4|
|Journal||Research Journal of Pharmaceutical, Biological and Chemical Sciences|
|Publication status||Published - 01-07-2016|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)