Pyrazinamide induced maculopapular rash: A rare case report

O. Balaji, T. Sereen Rose, K. Laxminarayana Bairy, Aswini Mohaptra

Research output: Contribution to journalArticlepeer-review

Abstract

Non immediate allergic reactions (NIRs) to drugs, due to specific immunologic mechanisms, can be induced by many commercially available drugs Maculopapular exanthema (MPE) is the one among the commonest manifestation following NIRs. Cytokines are known to play a dominant role in causing MPE. T helper 1 (Th1) cytokines and CD4 (+) T cells play a very pivotal role in the pathogenesis of this condition. As a part of pharmaovigilance program we hereby report a case of Maculopapular rash induced by pyrazinamide in a patient treated for pulmonary tuberculosis. The causality, severity, and preventability assessment of the adverse drug reaction was done to establish a causal relationship.

Original languageEnglish
Pages (from-to)2601-2604
Number of pages4
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume7
Issue number4
Publication statusPublished - 01-07-2016

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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