Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities

P.B. Miniyar; A.R. Bhat

Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities

P.B. Miniyar, A.R. Bhat

Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.

Original language	English
Pages (from-to)	155-156
Number of pages	2
Journal	Indian Journal of Heterocyclic Chemistry
Volume	9
Issue number	2
Publication status	Published - 1999

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Miniyar, P. B., & Bhat, A. R. (1999). Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities. Indian Journal of Heterocyclic Chemistry, 9(2), 155-156. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033258877&partnerID=40&md5=0b92ef2d4f3a86f68c12e21eed4bae12

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abstract = "A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.",

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AU - Miniyar, P.B.

AU - Bhat, A.R.

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N2 - A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.

AB - A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.

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SP - 155

EP - 156

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

SN - 0971-1627

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