Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities

P.B. Miniyar, A.R. Bhat

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.
Original languageEnglish
Pages (from-to)155-156
Number of pages2
JournalIndian Journal of Heterocyclic Chemistry
Volume9
Issue number2
Publication statusPublished - 1999

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