Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities

P.B. Miniyar, A.R. Bhat

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.
Original languageEnglish
Pages (from-to)155-156
Number of pages2
JournalIndian Journal of Heterocyclic Chemistry
Volume9
Issue number2
Publication statusPublished - 1999

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Derivatives
Pyrazinamide
Carboxylic acids
Acetic Acid
pyrazinoic acid

Cite this

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title = "Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities",
abstract = "A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.",
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Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities. / Miniyar, P.B.; Bhat, A.R.

In: Indian Journal of Heterocyclic Chemistry, Vol. 9, No. 2, 1999, p. 155-156.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities

AU - Miniyar, P.B.

AU - Bhat, A.R.

N1 - cited By 4

PY - 1999

Y1 - 1999

N2 - A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.

AB - A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.

M3 - Article

VL - 9

SP - 155

EP - 156

JO - Indian Journal of Heterocyclic Chemistry

JF - Indian Journal of Heterocyclic Chemistry

SN - 0971-1627

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ER -