Abstract
A series of substituted pyrazinoic acid hydrazides has been prepared and examined for their in-vitro activity against Mycobacterium tuberculosis. The representative compounds of each series screened for antitubercular studies were active against the test organism Mycobacterium tuberculosis H37Rv strain. Pyrazinamide was hydrolyzed and esterified to get ethyl pyrazinoate. Ethyl pyrazinoate was reacted with substituted aromatic acid hydrazides and phenoxy acetic acid hydrazides to yield respective hydrazide derivatives.
| Original language | English |
|---|---|
| Pages (from-to) | 155-156 |
| Number of pages | 2 |
| Journal | Indian Journal of Heterocyclic Chemistry |
| Volume | 9 |
| Issue number | 2 |
| Publication status | Published - 1999 |
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Miniyar, P. B., & Bhat, A. R. (1999). Pyrazinoic acid hydrazide derivatives : Synthesis and antimycobacterial activities. Indian Journal of Heterocyclic Chemistry, 9(2), 155-156.