Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation

Shubhalaxmia, B. S. Manjunatha, K. Ananda, K. Subrahmanya Bhat

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number6
DOIs
Publication statusPublished - 01-06-2016

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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