Pyrimidinethione derivatives with tosyl substitution

Synthesis, and antimicrobial property investigation

Shubhalaxmia, B. S. Manjunatha, K. Ananda, K. Subrahmanya Bhat

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number6
DOIs
Publication statusPublished - 01-06-2016

Fingerprint

Chalcones
Mycobacterium smegmatis
Candida albicans
Staphylococcus aureus
Mass Spectrometry
Escherichia coli
Proton Magnetic Resonance Spectroscopy
Carbon-13 Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

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abstract = "Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.",
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Pyrimidinethione derivatives with tosyl substitution : Synthesis, and antimicrobial property investigation. / Shubhalaxmia; Manjunatha, B. S.; Ananda, K.; Subrahmanya Bhat, K.

In: Journal of Applied Pharmaceutical Science, Vol. 6, No. 6, 01.06.2016, p. 73-78.

Research output: Contribution to journalArticle

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