Abstract
Estimation of proteinuria in children is cumbersome when a 24 h urine collection is needed. In the presence of a stable glomerular filtration rate, the ratio of urinary protein and creatinine should reflect the protein excretion. One hundred samples of urine (24 h and random samples) were collected from 50 children with nephrotic syndrome, 25 with nephrotic syndrome in remission and 25 normal children. The 24 h urine total protein and random urine protein-creatinine ratio were assessed on these samples. Linear regression analysis of the results showed excellent correlation between the values (r = 0.81, p less than 0.001). A random urine protein-creatinine ratio of greater than 3.5 correlated with massive proteinuria, while a ratio less than 0.2 was suggestive of physiological values. The sensitivity, specificity, positive and negative predictive values of the protein-creatinine ratio in massive proteinuria were very high. We conclude that the random urine protein-creatinine ratio can be used reliably to assess the degree of proteinuria in children.
| Original language | English |
|---|---|
| Pages (from-to) | 463-467 |
| Number of pages | 5 |
| Journal | Indian Pediatrics |
| Volume | 28 |
| Issue number | 5 |
| Publication status | Published - 01-05-1991 |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
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Quantitation of proteinuria using protein-creatinine ratio in random urine samples. / Iyer, R. S.; Shailaja, S. N.; Bhaskaranand, N.; Baliga, M.; Venkatesh, A.
In: Indian Pediatrics, Vol. 28, No. 5, 01.05.1991, p. 463-467.Research output: Contribution to journal › Article
TY - JOUR
T1 - Quantitation of proteinuria using protein-creatinine ratio in random urine samples.
AU - Iyer, R. S.
AU - Shailaja, S. N.
AU - Bhaskaranand, N.
AU - Baliga, M.
AU - Venkatesh, A.
PY - 1991/5/1
Y1 - 1991/5/1
N2 - Estimation of proteinuria in children is cumbersome when a 24 h urine collection is needed. In the presence of a stable glomerular filtration rate, the ratio of urinary protein and creatinine should reflect the protein excretion. One hundred samples of urine (24 h and random samples) were collected from 50 children with nephrotic syndrome, 25 with nephrotic syndrome in remission and 25 normal children. The 24 h urine total protein and random urine protein-creatinine ratio were assessed on these samples. Linear regression analysis of the results showed excellent correlation between the values (r = 0.81, p less than 0.001). A random urine protein-creatinine ratio of greater than 3.5 correlated with massive proteinuria, while a ratio less than 0.2 was suggestive of physiological values. The sensitivity, specificity, positive and negative predictive values of the protein-creatinine ratio in massive proteinuria were very high. We conclude that the random urine protein-creatinine ratio can be used reliably to assess the degree of proteinuria in children.
AB - Estimation of proteinuria in children is cumbersome when a 24 h urine collection is needed. In the presence of a stable glomerular filtration rate, the ratio of urinary protein and creatinine should reflect the protein excretion. One hundred samples of urine (24 h and random samples) were collected from 50 children with nephrotic syndrome, 25 with nephrotic syndrome in remission and 25 normal children. The 24 h urine total protein and random urine protein-creatinine ratio were assessed on these samples. Linear regression analysis of the results showed excellent correlation between the values (r = 0.81, p less than 0.001). A random urine protein-creatinine ratio of greater than 3.5 correlated with massive proteinuria, while a ratio less than 0.2 was suggestive of physiological values. The sensitivity, specificity, positive and negative predictive values of the protein-creatinine ratio in massive proteinuria were very high. We conclude that the random urine protein-creatinine ratio can be used reliably to assess the degree of proteinuria in children.
UR - http://www.scopus.com/inward/record.url?scp=0026150488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026150488&partnerID=8YFLogxK
M3 - Article
C2 - 1752671
AN - SCOPUS:0026150488
VL - 28
SP - 463
EP - 467
JO - Indian Pediatrics
JF - Indian Pediatrics
SN - 0019-6061
IS - 5
ER -