Quantitation of proteinuria using protein-creatinine ratio in random urine samples.

R. S. Iyer, S. N. Shailaja, N. Bhaskaranand, M. Baliga, A. Venkatesh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Estimation of proteinuria in children is cumbersome when a 24 h urine collection is needed. In the presence of a stable glomerular filtration rate, the ratio of urinary protein and creatinine should reflect the protein excretion. One hundred samples of urine (24 h and random samples) were collected from 50 children with nephrotic syndrome, 25 with nephrotic syndrome in remission and 25 normal children. The 24 h urine total protein and random urine protein-creatinine ratio were assessed on these samples. Linear regression analysis of the results showed excellent correlation between the values (r = 0.81, p less than 0.001). A random urine protein-creatinine ratio of greater than 3.5 correlated with massive proteinuria, while a ratio less than 0.2 was suggestive of physiological values. The sensitivity, specificity, positive and negative predictive values of the protein-creatinine ratio in massive proteinuria were very high. We conclude that the random urine protein-creatinine ratio can be used reliably to assess the degree of proteinuria in children.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalIndian Pediatrics
Volume28
Issue number5
Publication statusPublished - 01-05-1991

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Proteinuria
Creatinine
Urine
Proteins
Nephrotic Syndrome
Urine Specimen Collection
Glomerular Filtration Rate
Linear Models
Regression Analysis
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Iyer, R. S., Shailaja, S. N., Bhaskaranand, N., Baliga, M., & Venkatesh, A. (1991). Quantitation of proteinuria using protein-creatinine ratio in random urine samples. Indian Pediatrics, 28(5), 463-467.
Iyer, R. S. ; Shailaja, S. N. ; Bhaskaranand, N. ; Baliga, M. ; Venkatesh, A. / Quantitation of proteinuria using protein-creatinine ratio in random urine samples. In: Indian Pediatrics. 1991 ; Vol. 28, No. 5. pp. 463-467.
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Iyer, RS, Shailaja, SN, Bhaskaranand, N, Baliga, M & Venkatesh, A 1991, 'Quantitation of proteinuria using protein-creatinine ratio in random urine samples.', Indian Pediatrics, vol. 28, no. 5, pp. 463-467.

Quantitation of proteinuria using protein-creatinine ratio in random urine samples. / Iyer, R. S.; Shailaja, S. N.; Bhaskaranand, N.; Baliga, M.; Venkatesh, A.

In: Indian Pediatrics, Vol. 28, No. 5, 01.05.1991, p. 463-467.

Research output: Contribution to journalArticle

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Iyer RS, Shailaja SN, Bhaskaranand N, Baliga M, Venkatesh A. Quantitation of proteinuria using protein-creatinine ratio in random urine samples. Indian Pediatrics. 1991 May 1;28(5):463-467.