Racial disparities in left main stenting

Insights from a real world inner city population

Tamam Mohamad, Sidakpal S. Panaich, Anas Alani, Apurva Badheka, Maithili Shenoy, Bashar Mohamad, Eyas Kanaan, Omaima Ali, Mahir Elder, Theodore L. Schreiber

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background Left main coronary artery (LMCA) disease is associated with significant cardiovascular mortality. The data on patient characteristics' predicting outcomes after LMCA revascularization is sparse. Methods A retrospective study of 227 patients with LMCA disease documented on coronary angiography from March 2000 to December 2008. Data included demographic variables, co-morbidities, cardiac function, and medications. Race was self-identified. The study outcome was a composite end-point including myocardial infarction (MI) and all-cause mortality. Cox proportional hazard analysis was performed to study the effect of various patient attributes including race and gender on the composite end-point. Results Baseline characteristics were specifically compared between individuals who had the study outcome versus those who did not. Mean age was higher in the group with study outcomes when compared to the group without any outcomes (64.3 ± 11.8 years versus 59.2 ± 13.6 years; p = 0.013). After the final multivariate regression analysis, only African American (AA) race and age were found to be independent predictors of adverse cardiac outcome at the end of the first year (race - hazard ratio (HR) 3.82, 95% confidence interval (CI) 1.38-10.62, p = 0.010; age - HR 1.08, 95% CI 1.04-1.13, p < 0.001) and at the end of the study (race - HR 2.71, 95% CI 1.44-5.10, p = 0.002; age - HR 1.03, 95% CI 1.01-1.08, p = 0.017). Conclusion In our study of patients with unprotected LMCA disease, AA race, and age were significantly predictive of poor prognosis following revascularization, while gender had no predictive value in prognosticating cardiovascular mortality.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalJournal of Interventional Cardiology
Volume26
Issue number1
DOIs
Publication statusPublished - 01-02-2013
Externally publishedYes

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Confidence Intervals
Population
Coronary Artery Disease
Outcome Assessment (Health Care)
African Americans
Mortality
Coronary Angiography
Coronary Vessels
Multivariate Analysis
Retrospective Studies
Myocardial Infarction
Regression Analysis
Demography
Morbidity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Mohamad, T., Panaich, S. S., Alani, A., Badheka, A., Shenoy, M., Mohamad, B., ... Schreiber, T. L. (2013). Racial disparities in left main stenting: Insights from a real world inner city population. Journal of Interventional Cardiology, 26(1), 43-48. https://doi.org/10.1111/j.1540-8183.2013.12012.x
Mohamad, Tamam ; Panaich, Sidakpal S. ; Alani, Anas ; Badheka, Apurva ; Shenoy, Maithili ; Mohamad, Bashar ; Kanaan, Eyas ; Ali, Omaima ; Elder, Mahir ; Schreiber, Theodore L. / Racial disparities in left main stenting : Insights from a real world inner city population. In: Journal of Interventional Cardiology. 2013 ; Vol. 26, No. 1. pp. 43-48.
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abstract = "Background Left main coronary artery (LMCA) disease is associated with significant cardiovascular mortality. The data on patient characteristics' predicting outcomes after LMCA revascularization is sparse. Methods A retrospective study of 227 patients with LMCA disease documented on coronary angiography from March 2000 to December 2008. Data included demographic variables, co-morbidities, cardiac function, and medications. Race was self-identified. The study outcome was a composite end-point including myocardial infarction (MI) and all-cause mortality. Cox proportional hazard analysis was performed to study the effect of various patient attributes including race and gender on the composite end-point. Results Baseline characteristics were specifically compared between individuals who had the study outcome versus those who did not. Mean age was higher in the group with study outcomes when compared to the group without any outcomes (64.3 ± 11.8 years versus 59.2 ± 13.6 years; p = 0.013). After the final multivariate regression analysis, only African American (AA) race and age were found to be independent predictors of adverse cardiac outcome at the end of the first year (race - hazard ratio (HR) 3.82, 95{\%} confidence interval (CI) 1.38-10.62, p = 0.010; age - HR 1.08, 95{\%} CI 1.04-1.13, p < 0.001) and at the end of the study (race - HR 2.71, 95{\%} CI 1.44-5.10, p = 0.002; age - HR 1.03, 95{\%} CI 1.01-1.08, p = 0.017). Conclusion In our study of patients with unprotected LMCA disease, AA race, and age were significantly predictive of poor prognosis following revascularization, while gender had no predictive value in prognosticating cardiovascular mortality.",
author = "Tamam Mohamad and Panaich, {Sidakpal S.} and Anas Alani and Apurva Badheka and Maithili Shenoy and Bashar Mohamad and Eyas Kanaan and Omaima Ali and Mahir Elder and Schreiber, {Theodore L.}",
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Mohamad, T, Panaich, SS, Alani, A, Badheka, A, Shenoy, M, Mohamad, B, Kanaan, E, Ali, O, Elder, M & Schreiber, TL 2013, 'Racial disparities in left main stenting: Insights from a real world inner city population', Journal of Interventional Cardiology, vol. 26, no. 1, pp. 43-48. https://doi.org/10.1111/j.1540-8183.2013.12012.x

Racial disparities in left main stenting : Insights from a real world inner city population. / Mohamad, Tamam; Panaich, Sidakpal S.; Alani, Anas; Badheka, Apurva; Shenoy, Maithili; Mohamad, Bashar; Kanaan, Eyas; Ali, Omaima; Elder, Mahir; Schreiber, Theodore L.

In: Journal of Interventional Cardiology, Vol. 26, No. 1, 01.02.2013, p. 43-48.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Racial disparities in left main stenting

T2 - Insights from a real world inner city population

AU - Mohamad, Tamam

AU - Panaich, Sidakpal S.

AU - Alani, Anas

AU - Badheka, Apurva

AU - Shenoy, Maithili

AU - Mohamad, Bashar

AU - Kanaan, Eyas

AU - Ali, Omaima

AU - Elder, Mahir

AU - Schreiber, Theodore L.

PY - 2013/2/1

Y1 - 2013/2/1

N2 - Background Left main coronary artery (LMCA) disease is associated with significant cardiovascular mortality. The data on patient characteristics' predicting outcomes after LMCA revascularization is sparse. Methods A retrospective study of 227 patients with LMCA disease documented on coronary angiography from March 2000 to December 2008. Data included demographic variables, co-morbidities, cardiac function, and medications. Race was self-identified. The study outcome was a composite end-point including myocardial infarction (MI) and all-cause mortality. Cox proportional hazard analysis was performed to study the effect of various patient attributes including race and gender on the composite end-point. Results Baseline characteristics were specifically compared between individuals who had the study outcome versus those who did not. Mean age was higher in the group with study outcomes when compared to the group without any outcomes (64.3 ± 11.8 years versus 59.2 ± 13.6 years; p = 0.013). After the final multivariate regression analysis, only African American (AA) race and age were found to be independent predictors of adverse cardiac outcome at the end of the first year (race - hazard ratio (HR) 3.82, 95% confidence interval (CI) 1.38-10.62, p = 0.010; age - HR 1.08, 95% CI 1.04-1.13, p < 0.001) and at the end of the study (race - HR 2.71, 95% CI 1.44-5.10, p = 0.002; age - HR 1.03, 95% CI 1.01-1.08, p = 0.017). Conclusion In our study of patients with unprotected LMCA disease, AA race, and age were significantly predictive of poor prognosis following revascularization, while gender had no predictive value in prognosticating cardiovascular mortality.

AB - Background Left main coronary artery (LMCA) disease is associated with significant cardiovascular mortality. The data on patient characteristics' predicting outcomes after LMCA revascularization is sparse. Methods A retrospective study of 227 patients with LMCA disease documented on coronary angiography from March 2000 to December 2008. Data included demographic variables, co-morbidities, cardiac function, and medications. Race was self-identified. The study outcome was a composite end-point including myocardial infarction (MI) and all-cause mortality. Cox proportional hazard analysis was performed to study the effect of various patient attributes including race and gender on the composite end-point. Results Baseline characteristics were specifically compared between individuals who had the study outcome versus those who did not. Mean age was higher in the group with study outcomes when compared to the group without any outcomes (64.3 ± 11.8 years versus 59.2 ± 13.6 years; p = 0.013). After the final multivariate regression analysis, only African American (AA) race and age were found to be independent predictors of adverse cardiac outcome at the end of the first year (race - hazard ratio (HR) 3.82, 95% confidence interval (CI) 1.38-10.62, p = 0.010; age - HR 1.08, 95% CI 1.04-1.13, p < 0.001) and at the end of the study (race - HR 2.71, 95% CI 1.44-5.10, p = 0.002; age - HR 1.03, 95% CI 1.01-1.08, p = 0.017). Conclusion In our study of patients with unprotected LMCA disease, AA race, and age were significantly predictive of poor prognosis following revascularization, while gender had no predictive value in prognosticating cardiovascular mortality.

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U2 - 10.1111/j.1540-8183.2013.12012.x

DO - 10.1111/j.1540-8183.2013.12012.x

M3 - Article

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SP - 43

EP - 48

JO - Journal of Interventional Cardiology

JF - Journal of Interventional Cardiology

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