Radiolabelled nanoparticles in cancer management: Current status and developments

Sumeet Suresh Malapure, Shivanand Bhushan, Rajesh Kumar, Sanjay Bharati

Research output: Contribution to journalShort survey

1 Citation (Scopus)

Abstract

The current concepts of cancer therapy are moving towards personalized treatment regimen aiming to improve efficacy and reduce toxicity of therapeutic agents. With the development of molecular imaging and targeted therapies, personalized care has received a shot in the arm. However, these developments are not without challenges. Drug delivery, metabolism, toxicity etc., challenge the effective utilization of such agents. Nanoparticles offer to overcome these hurdles with their unique physico-chemical properties. These particles can be labelled with radionuclides and conjugated with ligands to achieve high specific activity in the intended areas. In this article, we discuss the present status of radiolabelled nanoparticles, the areas where they are being used and challenges that lie ahead. We intend to provide a basic outlook on the utilization of radiolabelled nanoparticles in cancer diagnosis and therapy.

Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalChemical Biology Letters
Volume5
Issue number1
Publication statusPublished - 01-01-2018

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry, medical

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