Radioprotective effect of ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure

Lebana J. Joseph, Uma S. Bhartiya, Yogita S. Raut, Rohini W. Hawaldar, Yogendra Nayak, Yogita P. Pawar, Nirmala A. Jambhekar, M. G R Rajan

Research output: Contribution to journalArticle

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Abstract

The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ( 131I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) 131I exposure. Six months duration batch received 131I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before 131I exposure separately. Increased Technetium-99m-pertechnetate ( 99mTcO 4 -) uptake at 30 minutes post injection in salivary glands of only 131I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only 131I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to 131I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose 131I exposure.

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalCancer Biotherapy and Radiopharmaceuticals
Volume26
Issue number6
DOIs
Publication statusPublished - 01-12-2011

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Amifostine
Salivary Glands
Therapeutics
Lipomatosis
Sodium Pertechnetate Tc 99m
Parotid Gland
Technetium
Atrophy
Ocimum sanctum
Histology
Injections

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology

Cite this

Joseph, Lebana J. ; Bhartiya, Uma S. ; Raut, Yogita S. ; Hawaldar, Rohini W. ; Nayak, Yogendra ; Pawar, Yogita P. ; Jambhekar, Nirmala A. ; Rajan, M. G R. / Radioprotective effect of ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure. In: Cancer Biotherapy and Radiopharmaceuticals. 2011 ; Vol. 26, No. 6. pp. 737-743.
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Radioprotective effect of ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure. / Joseph, Lebana J.; Bhartiya, Uma S.; Raut, Yogita S.; Hawaldar, Rohini W.; Nayak, Yogendra; Pawar, Yogita P.; Jambhekar, Nirmala A.; Rajan, M. G R.

In: Cancer Biotherapy and Radiopharmaceuticals, Vol. 26, No. 6, 01.12.2011, p. 737-743.

Research output: Contribution to journalArticle

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N2 - The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ( 131I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) 131I exposure. Six months duration batch received 131I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before 131I exposure separately. Increased Technetium-99m-pertechnetate ( 99mTcO 4 -) uptake at 30 minutes post injection in salivary glands of only 131I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only 131I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to 131I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose 131I exposure.

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