Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro

V. Satya Prasad, P. Uma Devi, B. S. Satish Rao, Ravindra Kamath

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Mouse melanoma cells were treated with plumbagin, a naphthoquinone, from the plant Plumbago rosea at 0.5 μg/ml (Pl) for 60 min either alone or followed by 2 Gy gamma radiation (RT). Response to the different treatments was assessed by following the cell growth up to 5 days post treatment. Pl alone produced a significant decrease in the cell count on days 3 and 4, whereas RT treatment significantly decreased the cell count 24 hr after the exposure, which persisted till day 4. Pl treatment before RT significantly enhanced the growth inhibitory effect when compared to RT or Pl alone. These findings suggests the radiosensitizing effect of Pl on mouse melanoma cells in vitro, supporting the earlier in vivo findings.

Original languageEnglish
Pages (from-to)857-858
Number of pages2
JournalIndian Journal of Experimental Biology
Volume34
Issue number9
Publication statusPublished - 09-1996

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Radiation-Sensitizing Agents
Melanoma
Radiation
Plumbaginaceae
Cell Count
Naphthoquinones
Radiation Dosage
Gamma Rays
Growth
plumbagin
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Medicine(all)
  • Molecular Biology
  • Cell Biology

Cite this

Satya Prasad, V. ; Uma Devi, P. ; Satish Rao, B. S. ; Kamath, Ravindra. / Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro. In: Indian Journal of Experimental Biology. 1996 ; Vol. 34, No. 9. pp. 857-858.
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Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro. / Satya Prasad, V.; Uma Devi, P.; Satish Rao, B. S.; Kamath, Ravindra.

In: Indian Journal of Experimental Biology, Vol. 34, No. 9, 09.1996, p. 857-858.

Research output: Contribution to journalArticle

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