Raman spectroscopy of breast tissues

C. Murali Krishna, Jacob Kurien, Stanley Mathew, Lakshmi Rao, Kodali Maheedhar, Kakarla Kalyan Kumar, Maneni Venkata Purushottam Chowdary

Research output: Contribution to journalReview article

39 Citations (Scopus)

Abstract

Breast cancer is one of the leading female cancers. The major drawback of the gold standard of screening, mammography, is the high rate of false reports, aside from the risk from repeated exposure to harmful ionizing radiations. Histopathology, the gold standard of diagnosis, is time consuming and often prone to subjective interpretations. Molecular level diagnosis 'omics' is becoming increasingly popular; among these is metabolomics, diagnosis based on 'metabolic fingerprinting'. In the present article we review a Raman spectroscopic approach to metabolic fingerprinting in breast cancer detection. This review opens with a brief background on anatomical and etiological aspects of breast cancers. We present an overview of conventional detection approaches in breast cancer screening and diagnosis methods, followed by a concise note on the basics of optical spectroscopy and its applications in the screening/diagnosis of breast malignancy. We present the recent developments in Raman spectroscopic diagnosis of breast cancers and also share our experience in Raman spectroscopic classification of normal, benign and malignant breast tissues. Perspectives and current status of Raman spectroscopic screening/diagnosis of breast cancers are also discussed.

Original languageEnglish
Pages (from-to)149-166
Number of pages18
JournalExpert Review of Molecular Diagnostics
Volume8
Issue number2
DOIs
Publication statusPublished - 01-03-2008

Fingerprint

Raman Spectrum Analysis
Breast
Breast Neoplasms
Metabolomics
Mammography
Ionizing Radiation
Early Detection of Cancer
Neoplasms
Spectrum Analysis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Krishna, C. M., Kurien, J., Mathew, S., Rao, L., Maheedhar, K., Kumar, K. K., & Chowdary, M. V. P. (2008). Raman spectroscopy of breast tissues. Expert Review of Molecular Diagnostics, 8(2), 149-166. https://doi.org/10.1586/14737159.8.2.149
Krishna, C. Murali ; Kurien, Jacob ; Mathew, Stanley ; Rao, Lakshmi ; Maheedhar, Kodali ; Kumar, Kakarla Kalyan ; Chowdary, Maneni Venkata Purushottam. / Raman spectroscopy of breast tissues. In: Expert Review of Molecular Diagnostics. 2008 ; Vol. 8, No. 2. pp. 149-166.
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Krishna, CM, Kurien, J, Mathew, S, Rao, L, Maheedhar, K, Kumar, KK & Chowdary, MVP 2008, 'Raman spectroscopy of breast tissues', Expert Review of Molecular Diagnostics, vol. 8, no. 2, pp. 149-166. https://doi.org/10.1586/14737159.8.2.149

Raman spectroscopy of breast tissues. / Krishna, C. Murali; Kurien, Jacob; Mathew, Stanley; Rao, Lakshmi; Maheedhar, Kodali; Kumar, Kakarla Kalyan; Chowdary, Maneni Venkata Purushottam.

In: Expert Review of Molecular Diagnostics, Vol. 8, No. 2, 01.03.2008, p. 149-166.

Research output: Contribution to journalReview article

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Krishna CM, Kurien J, Mathew S, Rao L, Maheedhar K, Kumar KK et al. Raman spectroscopy of breast tissues. Expert Review of Molecular Diagnostics. 2008 Mar 1;8(2):149-166. https://doi.org/10.1586/14737159.8.2.149