Real eyes realizes real lies

A case report and review of nuisance antibodies in immunohematology

Dhivya Kandasamy, Shamee Shastry, Deepika Chenna, Ganesh Mohan

Research output: Contribution to journalArticle

Abstract

Detection of nonspecific antibodies unrelated to blood group antigen that causes nuisance in pretransfusion testing is a rare event. Their interpretation is often made only after the exclusion of all possible clinically significant antibodies and results in the unnecessary expenditure of reagents and human resources. We report one such nuisance antibody detected in an antenatal female that showed pan reaction with antibody screening and identification panel red cells including auto control but was compatible with group-specific donor units. Direct antiglobulin test was positive with no hematological evidence of bleeding. Repeat antibody screening test performed after washing the panel red cells and use of panel cells from different manufacturer showed negative reaction raising the suspicion of antibody specificity against chemical constituents in suspension medium of panel cells. Interpretation of nonspecific antibodies as to what they really are demands extensive immunohematological work-up and causes a delay in issue of blood components to the recipient.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalAsian Journal of Transfusion Science
Volume12
Issue number2
DOIs
Publication statusPublished - 01-07-2018

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Antibodies
Coombs Test
Antibody Specificity
Blood Group Antigens
Health Expenditures
Suspensions
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Hematology

Cite this

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Real eyes realizes real lies : A case report and review of nuisance antibodies in immunohematology. / Kandasamy, Dhivya; Shastry, Shamee; Chenna, Deepika; Mohan, Ganesh.

In: Asian Journal of Transfusion Science, Vol. 12, No. 2, 01.07.2018, p. 169-172.

Research output: Contribution to journalArticle

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