Recent advancements in spectrophotometric pka determinations: A review

Job Herman Berkhout, H. N. Aswatha Ram

Research output: Contribution to journalArticle

Abstract

The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.

Original languageEnglish
Pages (from-to)S475-S480
JournalIndian Journal of Pharmaceutical Education and Research
Volume53
Issue number4
DOIs
Publication statusPublished - 01-10-2019

Fingerprint

Pharmaceutical Preparations
Spectrum Analysis
Costs and Cost Analysis

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

@article{d7ed009f33024798b1865bcbf4fee8c5,
title = "Recent advancements in spectrophotometric pka determinations: A review",
abstract = "The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.",
author = "Berkhout, {Job Herman} and {Aswatha Ram}, {H. N.}",
year = "2019",
month = "10",
day = "1",
doi = "10.5530/ijper.53.4s.141",
language = "English",
volume = "53",
pages = "S475--S480",
journal = "Indian Journal of Pharmaceutical Education and Research",
issn = "0019-5464",
publisher = "Association of Pharmaceutical Teachers of India",
number = "4",

}

Recent advancements in spectrophotometric pka determinations : A review. / Berkhout, Job Herman; Aswatha Ram, H. N.

In: Indian Journal of Pharmaceutical Education and Research, Vol. 53, No. 4, 01.10.2019, p. S475-S480.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recent advancements in spectrophotometric pka determinations

T2 - A review

AU - Berkhout, Job Herman

AU - Aswatha Ram, H. N.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.

AB - The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.

UR - http://www.scopus.com/inward/record.url?scp=85075220341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85075220341&partnerID=8YFLogxK

U2 - 10.5530/ijper.53.4s.141

DO - 10.5530/ijper.53.4s.141

M3 - Article

AN - SCOPUS:85075220341

VL - 53

SP - S475-S480

JO - Indian Journal of Pharmaceutical Education and Research

JF - Indian Journal of Pharmaceutical Education and Research

SN - 0019-5464

IS - 4

ER -