Recent advances in co-amorphous drug formulations

Swapnil Jayant Dengale, Holger Grohganz, Thomas Rades, Korbinian Löbmann

Research output: Contribution to journalReview article

163 Citations (Scopus)

Abstract

Co-amorphous drug delivery systems have recently gained considerable interest in the pharmaceutical field because of their potential to improve oral bioavailability of poorly water-soluble drugs through drug dissolution enhancement as a result of the amorphous nature of the material. A co-amorphous system is characterized by the use of only low molecular weight components that are mixed into a homogeneous single-phase co-amorphous blend. The use of only low molecular weight co-formers makes this approach very attractive, as the amount of amorphous stabilizer can be significantly reduced compared with other amorphous stabilization techniques. Because of this, several research groups started to investigate the co-amorphous formulation approach, resulting in an increasing amount of scientific publications over the last few years. This study provides an overview of the co-amorphous field and its recent findings. In particular, we investigate co-amorphous formulations from the viewpoint of solid dispersions, describe their formation and mechanism of stabilization, study their impact on dissolution and in vivo performance and briefly outline the future potentials.

Original languageEnglish
Pages (from-to)116-125
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume100
DOIs
Publication statusPublished - 01-05-2016

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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