Recent advances in human brown fat physiology

D. V. Muralidhara, Krithika D. Muralidhara

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Of the two variants of adipose tissue, white fat is traditionally known as a lipid rich tissue which undergoes pathological expansion in obese conditions. To counter the excess accumulation of white fat in states of energy imbalance, the second and unique type of brown fat plays a key role by burning extra energy into heat through a special metabolic pathway. In addition brown fat also plays a vital role in thermoregulation in animals and newborn humans and infants. Recent progress in research areas of these two types of fat tissue has provided compelling evidence to show that they secrete a large number of chemicals that play an important role in body weight control that involves several mechanisms. Brown fat was considered absent in the adult humans until recently. But new techniques have provided ample support for its active existence. Based on the very recent data it has been suggested that brown fat can be a target organ in the treatment of obesity which can lead to exciting and informative outcomes in the future.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalIndian Journal of Physiology and Pharmacology
Issue number3
Publication statusPublished - 01-07-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)


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