Recent developments in floating drug delivery systems for gastric retention of drugs, an overview

A.A. Shirwaikar, S.M.R. Kumar, S. Jacob, W. Rashi, K. Ravi

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The floating drug delivery system (FDDS) design appears to be one of the most effective and rational approaches for the controlled oral drug delivery. This FDDS appears to have a distinct advantage in delivering the drugs that are absorbed mainly in the upper part of the GI tract and drugs having stability and solubility problem in the lower part of the intestine. This area of research therefore should be aimed at developing the dosage forms to increase the pharmacokinetic profile of the drugs. There are various natural polymers and gums, which need to be explored to find their use in the designing of floating dosage forms, which have a high potential for the commercialization of the drugs. An attempt has been made in this review article to introduce the readers to the current technology development in floating drug delivery system.
Original languageEnglish
Pages (from-to)697-704
Number of pages8
JournalIndian Drugs
Volume43
Issue number9
Publication statusPublished - 2006
Externally publishedYes

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Gastrointestinal Agents
Drug Delivery Systems
Dosage Forms
Pharmaceutical Preparations
Drug Stability
Upper Gastrointestinal Tract
Gingiva
Solubility
Intestines
Polymers
Pharmacokinetics
Research

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Shirwaikar, A. A., Kumar, S. M. R., Jacob, S., Rashi, W., & Ravi, K. (2006). Recent developments in floating drug delivery systems for gastric retention of drugs, an overview. Indian Drugs, 43(9), 697-704.
Shirwaikar, A.A. ; Kumar, S.M.R. ; Jacob, S. ; Rashi, W. ; Ravi, K. / Recent developments in floating drug delivery systems for gastric retention of drugs, an overview. In: Indian Drugs. 2006 ; Vol. 43, No. 9. pp. 697-704.
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abstract = "The floating drug delivery system (FDDS) design appears to be one of the most effective and rational approaches for the controlled oral drug delivery. This FDDS appears to have a distinct advantage in delivering the drugs that are absorbed mainly in the upper part of the GI tract and drugs having stability and solubility problem in the lower part of the intestine. This area of research therefore should be aimed at developing the dosage forms to increase the pharmacokinetic profile of the drugs. There are various natural polymers and gums, which need to be explored to find their use in the designing of floating dosage forms, which have a high potential for the commercialization of the drugs. An attempt has been made in this review article to introduce the readers to the current technology development in floating drug delivery system.",
author = "A.A. Shirwaikar and S.M.R. Kumar and S. Jacob and W. Rashi and K. Ravi",
note = "Cited By :12 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Shirwaikar, A. A.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal, Karnataka-576104, India; email: arunshirwaikar@yahoo.co.in References: Kim, H.K., Singh, B.N., Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention (2000) J.Control. Release., 63, pp. 235-259; Vyas, S.P., Khar, R.K., (2002) Controlled Delivery Concepts and Advances, pp. 156+201+196. , 1st edition; Vallabh Prakashan, Delhi; Kawashima, Y., Niwa, T., Takeuchi, H., Ito, H., Preparation of multiple unit hollow microspheres with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behaviour (in vivo) (1991) J.Control. Release., 16, pp. 279-290; Rouge, N., Leroux, J.C., Cole, E.T., Doelker, E., Burt, P., Prevention of the sticking tendency of floating mini tablets filled into hard gelatin capsules (1997) Eur. J. Pharm. Biopharm., 43, pp. 165-171; Hilton, A.K., Deasy, P.B., In vitro and in vitro evaluation of an oral sustained release dosage forms of amoxicillin trihydrate (1992) Int. J. Pharm., 86, pp. 79-80; Desai, S., Bolton, S., A floating controlled release drug delivery system, in vitro and in vivo evaluation (1993) Pharm. Res., 10, pp. 1321-1325; Menon, A., Ritschel, W.A., Sarkar, A., Development and evaluation of a monolithic floating dosage form for furosemide (1994) J. Pharm. Sci., 83, pp. 239-245; Kohri, N., Naasari, I., Mitataki, K., Improving the oral bioavailability of sulpiride by a gastric retained form in rabbits (1995) J. Pharm. Pharmacol., 48, pp. 371-374; Arati, A.D., Navnit, H.S., Christopher, T.R., Waseem, M., Development of a novel controlled release systems for gastric retention (1997) Pharm. Res., 14, pp. 809-812; Iannuccelli, V., Coppi, G., Sansone, R., Ferolla, G., Air compartment multiple unit system for prolonged gastric residence. Part-I. Formulation study (1998) Int. J. Pharm., 174, pp. 47-54; Yang, L., Eshraghi, J., Fassihi, R., A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: In vitro evaluation (1999) Journal of Controlled Release, 57 (3), pp. 215-222. , DOI 10.1016/S0168-3659(98)00066-2, PII S0168365998000662; Ushimaru, K., Nakamichi, H.S., Pharmaceutical preparations and a method of manufacturing them (1987), US Patent., 4,702,918; Fell, J.T., Whitehead, L., Collet, J.H., Amoxycillin release from a floating dosage form based on alginates (2000) Int. J. Pharm., 210, pp. 45-49; Mitra, S.B., Sustained release oral medicinal delivery device (1984), US Patent., 4,451,260; Thanoo, B.C., Sunny, M.C., Jayakrihnan, A., Oral sustained release drug delivery systems using polycarbonate microspheres capable of floating on gastric fluid (1993) J. Pharm. Pharmacol., 45, pp. 21-24; Baumgartnar, S., Julijana, K., Franc, C., Zorco, B., Optimization of floating matrix tablets and evaluation of their gastric residence time (2000) Int. J. Pharm., 195, pp. 125-135; Bulgarelli, E., Forni, F., Bernabei, M.T., Effect of matrix composition and process condition on casein -gelatin beads floating properties (2000) Int. J. Pharm., 198, pp. 157-165; Nur, A.O., Zhang, J.S., Captopril floating and/or bioadhesive tablets: Design and release kinetics (2000) Drug Develop. Ind. Pharm., 26, pp. 965-969; Naggar, V.F., El-Kamel, A.H., Sokar, M.S., Al Gamal, S.S., Preparation and evaluation of ketoprofen floating oral delivery system (2001) Int. J. Pharm., 220, pp. 13-21; Fassihi, R., Talukider, R., Gastro retentive delivery system: Hollow beads (2004) Drug Develop. Ind. Pharm., 30, pp. 405-412; Rubinstein, A., Friend, D.R., Specific Delivery to gastrointestinal tract (1994) Polymeric Site Specific Pharmacotherapy, pp. 282-283. , Wiley: Chichester; Hashim, H., Li Wan Po, A., Improving the release characteristics of water- Soluble drugs from hydrophilic sustained release matrices by in-situ gas generation (1987) Int. J. Pharm., 35, pp. 201-209; Ingani, H.M., Timmermans, J., Moes, A.J., Conception and in vivo investigation of peroral sustained release floating dosage forms with enhanced gastrointestinal transit (1987) Int. J. Pharm., 35, pp. 157-164; Ichikawa, M., Watnabe, S., Miyake, Y., A new multiple unit oral floating dosage system I -Preparation and invitro evaluation of floating and sustained release characteristics (1991) J. Pharm. Sci., 80, pp. 1062-1066; Inouye, K., Machida, Y., Sannan, T., Nagni, T., Buoyant sustained release tablets based on chitosan (1988) Drug. Des. Del., 2, pp. 165-175; Umezawa, H., Pepstatin floating mini capsules (1978), US Patent., 4,101,650; Stockwell, A.F., Davis, S.S., Walker, S.E., Invitro evaluation of alginate gel systems as sustained release drug delivery systems (1986) J. Control. Release., 3, pp. 167-175; Ichikawa, M., Watanabe, S., Miyake, Y., Granule remain in stomach (1989), US patent., 4844905; Atyabi, F., Sharma, H.L., Mohammed, H.A.H., Fell, J.T., Controlled drug release from coating floating ion exchange resin beads (1996) J. Control. Release., 42, pp. 25-28; Todd, R.S., Fryers, G.R., Cholestyramine compositions and method for treating biliary gastritis (1979), US Patent., 4,172,120UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953841344&partnerID=40&md5=9a61d22f37d043cb1828d72c056f2516",
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Shirwaikar, AA, Kumar, SMR, Jacob, S, Rashi, W & Ravi, K 2006, 'Recent developments in floating drug delivery systems for gastric retention of drugs, an overview', Indian Drugs, vol. 43, no. 9, pp. 697-704.

Recent developments in floating drug delivery systems for gastric retention of drugs, an overview. / Shirwaikar, A.A.; Kumar, S.M.R.; Jacob, S.; Rashi, W.; Ravi, K.

In: Indian Drugs, Vol. 43, No. 9, 2006, p. 697-704.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recent developments in floating drug delivery systems for gastric retention of drugs, an overview

AU - Shirwaikar, A.A.

AU - Kumar, S.M.R.

AU - Jacob, S.

AU - Rashi, W.

AU - Ravi, K.

N1 - Cited By :12 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Shirwaikar, A. A.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal, Karnataka-576104, India; email: arunshirwaikar@yahoo.co.in References: Kim, H.K., Singh, B.N., Floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention (2000) J.Control. Release., 63, pp. 235-259; Vyas, S.P., Khar, R.K., (2002) Controlled Delivery Concepts and Advances, pp. 156+201+196. , 1st edition; Vallabh Prakashan, Delhi; Kawashima, Y., Niwa, T., Takeuchi, H., Ito, H., Preparation of multiple unit hollow microspheres with acrylic resin containing tranilast and their drug release characteristics (in vitro) and floating behaviour (in vivo) (1991) J.Control. Release., 16, pp. 279-290; Rouge, N., Leroux, J.C., Cole, E.T., Doelker, E., Burt, P., Prevention of the sticking tendency of floating mini tablets filled into hard gelatin capsules (1997) Eur. J. Pharm. Biopharm., 43, pp. 165-171; Hilton, A.K., Deasy, P.B., In vitro and in vitro evaluation of an oral sustained release dosage forms of amoxicillin trihydrate (1992) Int. J. Pharm., 86, pp. 79-80; Desai, S., Bolton, S., A floating controlled release drug delivery system, in vitro and in vivo evaluation (1993) Pharm. Res., 10, pp. 1321-1325; Menon, A., Ritschel, W.A., Sarkar, A., Development and evaluation of a monolithic floating dosage form for furosemide (1994) J. Pharm. Sci., 83, pp. 239-245; Kohri, N., Naasari, I., Mitataki, K., Improving the oral bioavailability of sulpiride by a gastric retained form in rabbits (1995) J. Pharm. Pharmacol., 48, pp. 371-374; Arati, A.D., Navnit, H.S., Christopher, T.R., Waseem, M., Development of a novel controlled release systems for gastric retention (1997) Pharm. Res., 14, pp. 809-812; Iannuccelli, V., Coppi, G., Sansone, R., Ferolla, G., Air compartment multiple unit system for prolonged gastric residence. Part-I. Formulation study (1998) Int. J. Pharm., 174, pp. 47-54; Yang, L., Eshraghi, J., Fassihi, R., A new intragastric delivery system for the treatment of Helicobacter pylori associated gastric ulcer: In vitro evaluation (1999) Journal of Controlled Release, 57 (3), pp. 215-222. , DOI 10.1016/S0168-3659(98)00066-2, PII S0168365998000662; Ushimaru, K., Nakamichi, H.S., Pharmaceutical preparations and a method of manufacturing them (1987), US Patent., 4,702,918; Fell, J.T., Whitehead, L., Collet, J.H., Amoxycillin release from a floating dosage form based on alginates (2000) Int. J. Pharm., 210, pp. 45-49; Mitra, S.B., Sustained release oral medicinal delivery device (1984), US Patent., 4,451,260; Thanoo, B.C., Sunny, M.C., Jayakrihnan, A., Oral sustained release drug delivery systems using polycarbonate microspheres capable of floating on gastric fluid (1993) J. Pharm. Pharmacol., 45, pp. 21-24; Baumgartnar, S., Julijana, K., Franc, C., Zorco, B., Optimization of floating matrix tablets and evaluation of their gastric residence time (2000) Int. J. Pharm., 195, pp. 125-135; Bulgarelli, E., Forni, F., Bernabei, M.T., Effect of matrix composition and process condition on casein -gelatin beads floating properties (2000) Int. J. Pharm., 198, pp. 157-165; Nur, A.O., Zhang, J.S., Captopril floating and/or bioadhesive tablets: Design and release kinetics (2000) Drug Develop. Ind. Pharm., 26, pp. 965-969; Naggar, V.F., El-Kamel, A.H., Sokar, M.S., Al Gamal, S.S., Preparation and evaluation of ketoprofen floating oral delivery system (2001) Int. J. Pharm., 220, pp. 13-21; Fassihi, R., Talukider, R., Gastro retentive delivery system: Hollow beads (2004) Drug Develop. Ind. Pharm., 30, pp. 405-412; Rubinstein, A., Friend, D.R., Specific Delivery to gastrointestinal tract (1994) Polymeric Site Specific Pharmacotherapy, pp. 282-283. , Wiley: Chichester; Hashim, H., Li Wan Po, A., Improving the release characteristics of water- Soluble drugs from hydrophilic sustained release matrices by in-situ gas generation (1987) Int. J. Pharm., 35, pp. 201-209; Ingani, H.M., Timmermans, J., Moes, A.J., Conception and in vivo investigation of peroral sustained release floating dosage forms with enhanced gastrointestinal transit (1987) Int. J. Pharm., 35, pp. 157-164; Ichikawa, M., Watnabe, S., Miyake, Y., A new multiple unit oral floating dosage system I -Preparation and invitro evaluation of floating and sustained release characteristics (1991) J. Pharm. Sci., 80, pp. 1062-1066; Inouye, K., Machida, Y., Sannan, T., Nagni, T., Buoyant sustained release tablets based on chitosan (1988) Drug. Des. Del., 2, pp. 165-175; Umezawa, H., Pepstatin floating mini capsules (1978), US Patent., 4,101,650; Stockwell, A.F., Davis, S.S., Walker, S.E., Invitro evaluation of alginate gel systems as sustained release drug delivery systems (1986) J. Control. Release., 3, pp. 167-175; Ichikawa, M., Watanabe, S., Miyake, Y., Granule remain in stomach (1989), US patent., 4844905; Atyabi, F., Sharma, H.L., Mohammed, H.A.H., Fell, J.T., Controlled drug release from coating floating ion exchange resin beads (1996) J. Control. Release., 42, pp. 25-28; Todd, R.S., Fryers, G.R., Cholestyramine compositions and method for treating biliary gastritis (1979), US Patent., 4,172,120UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953841344&partnerID=40&md5=9a61d22f37d043cb1828d72c056f2516

PY - 2006

Y1 - 2006

N2 - The floating drug delivery system (FDDS) design appears to be one of the most effective and rational approaches for the controlled oral drug delivery. This FDDS appears to have a distinct advantage in delivering the drugs that are absorbed mainly in the upper part of the GI tract and drugs having stability and solubility problem in the lower part of the intestine. This area of research therefore should be aimed at developing the dosage forms to increase the pharmacokinetic profile of the drugs. There are various natural polymers and gums, which need to be explored to find their use in the designing of floating dosage forms, which have a high potential for the commercialization of the drugs. An attempt has been made in this review article to introduce the readers to the current technology development in floating drug delivery system.

AB - The floating drug delivery system (FDDS) design appears to be one of the most effective and rational approaches for the controlled oral drug delivery. This FDDS appears to have a distinct advantage in delivering the drugs that are absorbed mainly in the upper part of the GI tract and drugs having stability and solubility problem in the lower part of the intestine. This area of research therefore should be aimed at developing the dosage forms to increase the pharmacokinetic profile of the drugs. There are various natural polymers and gums, which need to be explored to find their use in the designing of floating dosage forms, which have a high potential for the commercialization of the drugs. An attempt has been made in this review article to introduce the readers to the current technology development in floating drug delivery system.

M3 - Article

VL - 43

SP - 697

EP - 704

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 9

ER -

Shirwaikar AA, Kumar SMR, Jacob S, Rashi W, Ravi K. Recent developments in floating drug delivery systems for gastric retention of drugs, an overview. Indian Drugs. 2006;43(9):697-704.