Recombinant activated factor VII in the management of acute fatty liver of pregnancy

A case report

K. Supriya, Suchitra Thunga, Athira Narayanan, Prakhar Singh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A 20-year-old woman, primigravida at 36+4 weeks' gestation presented with malaise, vomiting for 1 week, yellowish discoloration of the eyes for 3 days and loss of fetal movements. A clinical diagnosis of acute fatty liver with intrauterine fetal demise was made. Labor was induced with prostaglandin E2 gel and delivered vaginally. The post-partum period was complicated by atonic post-partum hemorrhage, an episode of seizure, recurrent hypoglycemic attack, hypokalemia and continuing coagulopathy. Supportive management in the intensive care unit using blood and blood products and injection recombinant activated factor VIIa to arrest the bleeding resulted in a successful outcome.

Original languageEnglish
Pages (from-to)1122-1125
Number of pages4
JournalJournal of Obstetrics and Gynaecology Research
DOIs
Publication statusPublished - 01-01-2015
Externally publishedYes

Fingerprint

Factor VIIa
Induced Labor
Hemorrhage
Fetal Movement
Fetal Death
Hypokalemia
Fatty Liver
Dinoprostone
Hypoglycemic Agents
Vomiting
Intensive Care Units
Seizures
Gels
Pregnancy
Injections
Acute fatty liver of pregnancy
recombinant FVIIa

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Supriya, K. ; Thunga, Suchitra ; Narayanan, Athira ; Singh, Prakhar. / Recombinant activated factor VII in the management of acute fatty liver of pregnancy : A case report. In: Journal of Obstetrics and Gynaecology Research. 2015 ; pp. 1122-1125.
@article{4349186c40f84a79b1acd7a5d74205f9,
title = "Recombinant activated factor VII in the management of acute fatty liver of pregnancy: A case report",
abstract = "A 20-year-old woman, primigravida at 36+4 weeks' gestation presented with malaise, vomiting for 1 week, yellowish discoloration of the eyes for 3 days and loss of fetal movements. A clinical diagnosis of acute fatty liver with intrauterine fetal demise was made. Labor was induced with prostaglandin E2 gel and delivered vaginally. The post-partum period was complicated by atonic post-partum hemorrhage, an episode of seizure, recurrent hypoglycemic attack, hypokalemia and continuing coagulopathy. Supportive management in the intensive care unit using blood and blood products and injection recombinant activated factor VIIa to arrest the bleeding resulted in a successful outcome.",
author = "K. Supriya and Suchitra Thunga and Athira Narayanan and Prakhar Singh",
year = "2015",
month = "1",
day = "1",
doi = "10.1111/jog.12684",
language = "English",
pages = "1122--1125",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",

}

Recombinant activated factor VII in the management of acute fatty liver of pregnancy : A case report. / Supriya, K.; Thunga, Suchitra; Narayanan, Athira; Singh, Prakhar.

In: Journal of Obstetrics and Gynaecology Research, 01.01.2015, p. 1122-1125.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Recombinant activated factor VII in the management of acute fatty liver of pregnancy

T2 - A case report

AU - Supriya, K.

AU - Thunga, Suchitra

AU - Narayanan, Athira

AU - Singh, Prakhar

PY - 2015/1/1

Y1 - 2015/1/1

N2 - A 20-year-old woman, primigravida at 36+4 weeks' gestation presented with malaise, vomiting for 1 week, yellowish discoloration of the eyes for 3 days and loss of fetal movements. A clinical diagnosis of acute fatty liver with intrauterine fetal demise was made. Labor was induced with prostaglandin E2 gel and delivered vaginally. The post-partum period was complicated by atonic post-partum hemorrhage, an episode of seizure, recurrent hypoglycemic attack, hypokalemia and continuing coagulopathy. Supportive management in the intensive care unit using blood and blood products and injection recombinant activated factor VIIa to arrest the bleeding resulted in a successful outcome.

AB - A 20-year-old woman, primigravida at 36+4 weeks' gestation presented with malaise, vomiting for 1 week, yellowish discoloration of the eyes for 3 days and loss of fetal movements. A clinical diagnosis of acute fatty liver with intrauterine fetal demise was made. Labor was induced with prostaglandin E2 gel and delivered vaginally. The post-partum period was complicated by atonic post-partum hemorrhage, an episode of seizure, recurrent hypoglycemic attack, hypokalemia and continuing coagulopathy. Supportive management in the intensive care unit using blood and blood products and injection recombinant activated factor VIIa to arrest the bleeding resulted in a successful outcome.

UR - http://www.scopus.com/inward/record.url?scp=84984650169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984650169&partnerID=8YFLogxK

U2 - 10.1111/jog.12684

DO - 10.1111/jog.12684

M3 - Article

SP - 1122

EP - 1125

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

ER -