Recurrent giant myofibroblastoma of a female breast leading to a diagnostic dilemma: A lesson learnt!

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Myofibroblastoma (MFB) is a rare benign mesenchymal tumor of the breast commonly reported in males. It is a spindle cell neoplasm exhibiting myofibroblastic differentiation with characteristic immunohistochemical staining. We report the case of a 68-year-old postmenopausal lady who had undergone left breast lump excision 4 months back that was reported as malignant, now presenting with a rapidly growing hard mass in the same breast with no palpable axillary lymph nodes. Metastatic work-up was negative and she was planned for a lumpectomy, frozen section and if malignant, proceed to a modified radical mastectomy. Frozen section revealed a benign tumor. The final histopathology was reported to be MFB of the breast. The purpose of this report is to highlight that MFB can also occur in postmenopausal women, can recur and the diagnostic dilemma of this condition, which could have led to a mastectomy, but was avoided.

Original languageEnglish
Pages (from-to)210-213
Number of pages4
JournalKuwait Medical Journal
Issue number2
Publication statusPublished - 06-2019


All Science Journal Classification (ASJC) codes

  • Medicine(all)

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