Most of the reactive lesions in the oral cavity arise from gingiva. Fibroma, focal fibrous hyperplasia, pyogenic granuloma, and peripheral ossifying fibroma are the commonly encountered lesions of gingiva. Peripheral ossifying fibroma (POF) frequently arises from the peripheral tissues like gingiva. It is commonly found in females, mostly in the anterior of the molar region. POF is predicted to arise from the cells of periodontal ligament due to close proximity of gingiva to periodontal ligament. Its exact origin is unclear. The present article describes the case of recurrent peripheral ossifying fibroma located in the right lower premolar region in a 23-year-old female patient. Clinical, radiographic and histologic features as well as differential diagnosis, treatment and follow-up are discussed in this report. Early diagnosis along with surgical excision and curettage of surrounding tissue is important for the prevention of recurrences. Early conservative management of lesion reduces the risk of progression of lesion, and frequent follow-up visits are required to evaluate for recurrences.
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