Reduced blood glutathione and erythrocyte stability in osteoarthritis

G. M. Rao, Sreelaxmi, A. Naser, Vandana

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Inflammation and oxidative stress are believed to function as primary degenerative mechanism in the development and progression of osteoarthritis. Oxidants can inactivate latent collagenase and potentiate the damage. In the present study an attempt was made to study the non-essential endogenous antioxidants like reduced glutathione (GSH) and uric acid levels. Reduced glutathione in R.B.C. levels decreased significantly (p= 0.011) in the osteoarthritic group. Plasma uric acid levels showed a tendency to increase, however remained statistically insignificant. Oxidative stress was studied by evaluating the percent hemolysis and the study group showed a significant increase (p= 0.001) when compared with the control group. There was a significant drop in the hemoglobin (Hb) level (p= 0.003) in the study group. Reduced levels of GSH allow peroxides to accumulate in RBC and hemolysis can occur due to their oxidative effect on the lipid RBC membrane, which may be one of the cause for the observed decrease in the erythrocyte stability reflected by the increase in the percent hemolysis and decrease in the Hb level.

Original languageEnglish
Pages (from-to)201-203
Number of pages3
JournalBiomedical Research
Volume16
Issue number3
Publication statusPublished - 01-10-2005

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Oxidative stress
Hemolysis
Uric Acid
Osteoarthritis
Glutathione
Hemoglobins
Blood
Erythrocytes
Peroxides
Oxidative Stress
Collagenases
Membrane Lipids
Oxidants
Antioxidants
Plasmas
Inflammation
Control Groups

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Rao, G. M. ; Sreelaxmi ; Naser, A. ; Vandana. / Reduced blood glutathione and erythrocyte stability in osteoarthritis. In: Biomedical Research. 2005 ; Vol. 16, No. 3. pp. 201-203.
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Rao, GM, Sreelaxmi, Naser, A & Vandana 2005, 'Reduced blood glutathione and erythrocyte stability in osteoarthritis', Biomedical Research, vol. 16, no. 3, pp. 201-203.

Reduced blood glutathione and erythrocyte stability in osteoarthritis. / Rao, G. M.; Sreelaxmi; Naser, A.; Vandana.

In: Biomedical Research, Vol. 16, No. 3, 01.10.2005, p. 201-203.

Research output: Contribution to journalArticle

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