Reflectance polarization ex vivo measurements of gastrointestinal carcinoma lesions for cancer diagnostics

S. Ilyov, D. Ivanov, Ts Genova, V. Mircheva, L. Zaharieva, B. Kolev, B. Vladimirov, H. Valkov, N. Mazumder, K. Sindhoora, O. Semyachkina-Glushkovskaya, L. Avramov, E. Borisova

Research output: Contribution to journalConference articlepeer-review

Abstract

The use of polarized light for biomedical diagnostics of skin and mucosa has already a long history. Prior studies have shown a contrast enhancement of the polarimetric values and in images of cancerous and healthy zones tissues. In the present study, reflectance-geometry polarization measurements were made with gastrointestinal tissue (GIT) samples containing normal and neoplastic mucosa. We investigated ex vivo the characteristic differences in the polarimetric parameters, including Stokes vector elements, degree of polarization, azimuth and ellipticity angles of cancerous and healthy colorectal tissues. A model PAX1000VIS/M polarimeter (400-700 nm, ThorLabs Inc.) was used in reflectance mode to obtain information about these polarimetric parameters of the GIT samples investigated. The most significant differences were observed in the long-wavelength region (>600 nm) in the case of circular polarization of the illuminating and probe axes of the measurement unit. Histological analysis was used as a "gold standard"to compare the optical and pathological diagnosis.

Original languageEnglish
Article number012041
JournalJournal of Physics: Conference Series
Volume1859
Issue number1
DOIs
Publication statusPublished - 09-04-2021
Event21st International Conference and School on Quantum Electronics: Laser Physics and Applications, ICSQE 2020 - Virtual, Online
Duration: 21-09-202025-09-2020

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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