TY - JOUR
T1 - Reflectance polarization ex vivo measurements of gastrointestinal carcinoma lesions for cancer diagnostics
AU - Ilyov, S.
AU - Ivanov, D.
AU - Genova, Ts
AU - Mircheva, V.
AU - Zaharieva, L.
AU - Kolev, B.
AU - Vladimirov, B.
AU - Valkov, H.
AU - Mazumder, N.
AU - Sindhoora, K.
AU - Semyachkina-Glushkovskaya, O.
AU - Avramov, L.
AU - Borisova, E.
N1 - Funding Information:
This work was supported by the National Science Fund of Bulgarian Ministry of Education and Science under grant #KP06-India-8/07.08.2019 “Polarization-sensitive fluorescence spectroscopy and microscopy for cancer detection”. The work of O. Semyachkina-Glushkovskaya and E. Borisova was partially supported by the Russian Science Foundation project #18-15-00139 “Optical technologies for early diagnostics of stomach cancer”. The polarimetric equipment used was purchased under the project DO-02-112/2008 "National center of biomedical photonics“.
Publisher Copyright:
© 2021 Published under licence by IOP Publishing Ltd.
PY - 2021/4/9
Y1 - 2021/4/9
N2 - The use of polarized light for biomedical diagnostics of skin and mucosa has already a long history. Prior studies have shown a contrast enhancement of the polarimetric values and in images of cancerous and healthy zones tissues. In the present study, reflectance-geometry polarization measurements were made with gastrointestinal tissue (GIT) samples containing normal and neoplastic mucosa. We investigated ex vivo the characteristic differences in the polarimetric parameters, including Stokes vector elements, degree of polarization, azimuth and ellipticity angles of cancerous and healthy colorectal tissues. A model PAX1000VIS/M polarimeter (400-700 nm, ThorLabs Inc.) was used in reflectance mode to obtain information about these polarimetric parameters of the GIT samples investigated. The most significant differences were observed in the long-wavelength region (>600 nm) in the case of circular polarization of the illuminating and probe axes of the measurement unit. Histological analysis was used as a "gold standard"to compare the optical and pathological diagnosis.
AB - The use of polarized light for biomedical diagnostics of skin and mucosa has already a long history. Prior studies have shown a contrast enhancement of the polarimetric values and in images of cancerous and healthy zones tissues. In the present study, reflectance-geometry polarization measurements were made with gastrointestinal tissue (GIT) samples containing normal and neoplastic mucosa. We investigated ex vivo the characteristic differences in the polarimetric parameters, including Stokes vector elements, degree of polarization, azimuth and ellipticity angles of cancerous and healthy colorectal tissues. A model PAX1000VIS/M polarimeter (400-700 nm, ThorLabs Inc.) was used in reflectance mode to obtain information about these polarimetric parameters of the GIT samples investigated. The most significant differences were observed in the long-wavelength region (>600 nm) in the case of circular polarization of the illuminating and probe axes of the measurement unit. Histological analysis was used as a "gold standard"to compare the optical and pathological diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=85104268289&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85104268289&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1859/1/012041
DO - 10.1088/1742-6596/1859/1/012041
M3 - Conference article
AN - SCOPUS:85104268289
SN - 1742-6588
VL - 1859
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
IS - 1
M1 - 012041
T2 - 21st International Conference and School on Quantum Electronics: Laser Physics and Applications, ICSQE 2020
Y2 - 21 September 2020 through 25 September 2020
ER -
