Refractory hypocalcemia precipitated by dual infection with typhoid fever and hepatitis A in a patient with congenital hypoparathyroidism

Suman S. Karanth, Ram Bhat, Anurag Gupta

Research output: Contribution to journalArticle

Abstract

We present this rare occurrence of a 17 yr old boy, a known case of congenital hypoparathyroidism, who presented with fever and jaundice for 8 days and 2 episodes of generalised tonic-clonic seizures. Premorbidly patient was on regular oral calcium supplementations with normal serum calcium levels. Investigations revealed severe hypocalcaemia (3.2 mg/dL), low 25 hydroxyvitamin D levels and hypomagnesaemia. The marked elevation of serum bilirubin was accompanied by derangement of liver enzymes. Microbiological investigations were confirmatory for both hepatitis A and typhoid fever. In spite of the aggressive management with intravenous calcium gluconate infusion, refractory hypocalcaemia persisted with recovery only after gradual decline in the bilirubin levels. We inferred that the cholestatic process produced by both acute viral hepatitis A and typhoid fever precipitated this state of refractory hypocalcaemia in the previously well preserved patient.

Original languageEnglish
Pages (from-to)667-668
Number of pages2
JournalAsian Pacific Journal of Tropical Medicine
Volume5
Issue number8
DOIs
Publication statusPublished - 01-08-2012

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Hypoparathyroidism
Hepatitis A
Hypocalcemia
Typhoid Fever
Bilirubin
Infection
Calcium Gluconate
Calcium
Jaundice
Serum
Seizures
Fever
Liver
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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Refractory hypocalcemia precipitated by dual infection with typhoid fever and hepatitis A in a patient with congenital hypoparathyroidism. / Karanth, Suman S.; Bhat, Ram; Gupta, Anurag.

In: Asian Pacific Journal of Tropical Medicine, Vol. 5, No. 8, 01.08.2012, p. 667-668.

Research output: Contribution to journalArticle

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