Regioselective reaction: synthesis and biological properties of some novel mannich bases incorporating arylnitro thiophene moiety

M. Babu, K. Sujatha, S. Shalini Shenoy, Balakrishna Kalluraya

Research output: Contribution to journalArticle

Abstract

The Mannich reaction of 3-(substituted)-4-[5-(p-nitrophenyl)-2- thienylidene] amino- 5-mercapto-1,2,4-triazoles (3) with formaldehyde and appropriate amine resulted in the regioselective formation of 1-aminomethyl-3-(substituted)-4-[5-(p-nitrophenyl)-2- thienylidene] amino-1,2,4-triazole-5-thiones (4). The structures of the new compounds were established on the basis of analytical and spectral data. The new compounds were tested for their antibacterial and antifungal activities. Most of the tested compounds showed significant antifungal activity, much higher than the standard.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume18
Issue number3
Publication statusPublished - 01-01-2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry

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