Regiospecific reaction: Synthesis and biological assay of some sydnone and triazole-containing Mannich derivatives

Balakrishna Kalluraya, Ganesha Rai, Satheesha Rai, Shalini Shenoy

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Abstract

Condensation of 3-substituted-4-amino-1,2,4-triazole-5-thiones 3 with 3-aryl-sydnone-4-carboxaldehyde 5 afforded a series of Schiff's bases 6. These Schiff's bases underwent Mannich reaction regiospecifically with morpholine and formaldehyde to give Mannich bases 7. The new compounds were characterized by spectral and analytical data. Biological screening results showed promising antibacterial and antifungal activities for these compounds.

Original languageEnglish
Pages (from-to)127-130
Number of pages4
JournalIndian Journal of Heterocyclic Chemistry
Volume14
Issue number2
Publication statusPublished - 01-10-2004

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All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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