Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications

Jeevan K. Shetty, Mungli Prakash, Mohammad S. Ibrahim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA1c). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2 diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe +2) and ferric (Fe+3) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase in free iron in Fe+3 state (p <0.01), HbA1c(p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated positively with HbA 1c (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool which is known to increase oxidant generation.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume23
Issue number1
DOIs
Publication statusPublished - 30-06-2008
Externally publishedYes

Fingerprint

Glycosylated Hemoglobin A
Medical problems
Type 2 Diabetes Mellitus
Iron
Lipid Peroxides
Ferritins
Serum
Sulfhydryl Compounds
Blood Glucose
Fasting
Oxidants
Hemoglobins
Proteins

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

@article{05acae657b0e4024acc6619b70047633,
title = "Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications",
abstract = "Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA1c). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2 diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe +2) and ferric (Fe+3) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase in free iron in Fe+3 state (p <0.01), HbA1c(p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated positively with HbA 1c (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool which is known to increase oxidant generation.",
author = "Shetty, {Jeevan K.} and Mungli Prakash and Ibrahim, {Mohammad S.}",
year = "2008",
month = "6",
day = "30",
doi = "10.1007/s12291-008-0016-4",
language = "English",
volume = "23",
pages = "67--70",
journal = "Indian Journal of Clinical Biochemistry",
issn = "0970-1915",
publisher = "Springer India",
number = "1",

}

Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications. / Shetty, Jeevan K.; Prakash, Mungli; Ibrahim, Mohammad S.

In: Indian Journal of Clinical Biochemistry, Vol. 23, No. 1, 30.06.2008, p. 67-70.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications

AU - Shetty, Jeevan K.

AU - Prakash, Mungli

AU - Ibrahim, Mohammad S.

PY - 2008/6/30

Y1 - 2008/6/30

N2 - Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA1c). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2 diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe +2) and ferric (Fe+3) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase in free iron in Fe+3 state (p <0.01), HbA1c(p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated positively with HbA 1c (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool which is known to increase oxidant generation.

AB - Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA1c). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2 diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe +2) and ferric (Fe+3) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase in free iron in Fe+3 state (p <0.01), HbA1c(p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated positively with HbA 1c (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool which is known to increase oxidant generation.

UR - http://www.scopus.com/inward/record.url?scp=45749110943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45749110943&partnerID=8YFLogxK

U2 - 10.1007/s12291-008-0016-4

DO - 10.1007/s12291-008-0016-4

M3 - Article

AN - SCOPUS:45749110943

VL - 23

SP - 67

EP - 70

JO - Indian Journal of Clinical Biochemistry

JF - Indian Journal of Clinical Biochemistry

SN - 0970-1915

IS - 1

ER -