Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling

Isgav Davidowitz, Yisrael Parmet, Silvi Frenkel-Toledo, Melanie C. Baniña, Nachum Soroker, John M. Solomon, Dario G. Liebermann, Mindy F. Levin, Sigal Berman

Research output: Contribution to journalArticle

Abstract

Background. Spasticity is common in patients with stroke, yet current quantification methods are insufficient for determining the relationship between spasticity and voluntary movement deficits. This is partly a result of the effects of spasticity on spatiotemporal characteristics of movement and the variability of voluntary movement. These can be captured by Gaussian mixture models (GMMs). Objectives. To determine the influence of spasticity on upper-limb voluntary motion, as assessed by the bidirectional Kullback-Liebler divergence (BKLD) between motion GMMs. Methods. A total of 16 individuals with subacute stroke and 13 healthy aged-equivalent controls reached to grasp 4 targets (near-center, contralateral, far-center, and ipsilateral). Two-dimensional GMMs (angle and time) were estimated for elbow extension motion. BKLD was computed for each individual and target, within the control group and between the control and stroke groups. Movement time, final elbow angle, average elbow velocity, and velocity smoothness were computed. Results. Between-group BKLDs were much larger than within control-group BKLDs. Between-group BKLDs for the near-center target were lower than those for the far-center and contralateral targets, but similar to that for the ipsilateral target. For those with stroke, the final angle was lower for the near-center target, and the average velocity was higher. Velocity smoothness was lower for the near-center than for the ipsilateral target. Elbow flexor and extensor passive muscle resistance (Modified Ashworth Scale) strongly explained BKLD values. Conclusions. Results support the view that individuals with poststroke spasticity have a velocity-dependent reduction in active elbow joint range and that BKLD can be used as an objective measure of the effects of spasticity on reaching kinematics.

Original languageEnglish
Pages (from-to)141-152
Number of pages12
JournalNeurorehabilitation and Neural Repair
Volume33
Issue number2
DOIs
Publication statusPublished - 01-02-2019

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Movement Disorders
Elbow
Upper Extremity
Stroke
Control Groups
Elbow Joint
Biomechanical Phenomena
Muscles

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Neurology
  • Clinical Neurology

Cite this

Davidowitz, Isgav ; Parmet, Yisrael ; Frenkel-Toledo, Silvi ; Baniña, Melanie C. ; Soroker, Nachum ; Solomon, John M. ; Liebermann, Dario G. ; Levin, Mindy F. ; Berman, Sigal. / Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling. In: Neurorehabilitation and Neural Repair. 2019 ; Vol. 33, No. 2. pp. 141-152.
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Relationship Between Spasticity and Upper-Limb Movement Disorders in Individuals With Subacute Stroke Using Stochastic Spatiotemporal Modeling. / Davidowitz, Isgav; Parmet, Yisrael; Frenkel-Toledo, Silvi; Baniña, Melanie C.; Soroker, Nachum; Solomon, John M.; Liebermann, Dario G.; Levin, Mindy F.; Berman, Sigal.

In: Neurorehabilitation and Neural Repair, Vol. 33, No. 2, 01.02.2019, p. 141-152.

Research output: Contribution to journalArticle

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AU - Davidowitz, Isgav

AU - Parmet, Yisrael

AU - Frenkel-Toledo, Silvi

AU - Baniña, Melanie C.

AU - Soroker, Nachum

AU - Solomon, John M.

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