Relationship of time interval between antenatal corticosteroid administrations to delivery with respiratory distress in preterm newborns

Shyamala Guruvare, Barnali Basu, Lavanya Rai, Leslie Lewis, Shripad Hebbar, Prashanth Adiga

Research output: Contribution to journalArticle

Abstract

Objectives: To assess the relationship of time interval between antenatal corticosteroid administration and delivery with respiratory distress in premature newborns. Settings: Tertiary level teaching hospital Population: Preterm deliveries between 28 and 34 weeks in the period of April 2011 to January 2013 where the mothers received one course of corticosteroid prophylaxis and fulfilled the selection criteria. Materials and methods: Perusal of the hospital records was made to gather antenatal information and the details of delivery and the newborn. The patients were divided based on the number of doses of steroids received into three groups. The patients receiving complete steroid prophylaxis was further divided based on the time interval between steroid administration and delivery into five groups: 0 to 7 days, 8 to 14, 15 to 21, 22 to 28, 29 days and beyond. We looked for association between neonatal respiratory outcomes and steroid­delivery intervals using Statistical Package for the Social Sciences version 16 (SPSS, Chicago, USA). Regression model was used to control for the confounding variables. Results: There were 284 women who delivered preterm (up to 34 weeks of gestation) between April 2011 and January 2013 and fulfilled the selection criteria. The babies who received one (48) or no dose of steroids (14) had a higher incidence of respiratory distress than the ones who received a complete dose. This was statistically significant for babies born up to 32 weeks. Among the rest 222 babies who received complete steroid prophylaxis, 138 (62%) of the neonates born were admitted in NICU, respiratory distress was seen in 62 (28%). Eleven (5%) of the babies required intubation and 22 (9%) required surfactant therapy; there were 12 (5%) neonatal deaths. Multivariable logistic regression analysis showed a slightly increased risk of respiratory morbidity with increased interval from administration to delivery (OR–0.87 for 8–14 days, 1.79 for 15–21 days and 0.16 for 22–28 days). Conclusion: The risk of respiratory distress in preterm newborns increases beyond 2 weeks interval between antenatal corticosteroid administration and delivery.

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalInternational Journal of Infertility and Fetal Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - 01-01-2015

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Adrenal Cortex Hormones
Steroids
Newborn Infant
Patient Selection
Confounding Factors (Epidemiology)
Hospital Records
Social Sciences
Intubation
Surface-Active Agents
Teaching Hospitals
Logistic Models
Regression Analysis
Mothers
Morbidity
Pregnancy
Incidence
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine

Cite this

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title = "Relationship of time interval between antenatal corticosteroid administrations to delivery with respiratory distress in preterm newborns",
abstract = "Objectives: To assess the relationship of time interval between antenatal corticosteroid administration and delivery with respiratory distress in premature newborns. Settings: Tertiary level teaching hospital Population: Preterm deliveries between 28 and 34 weeks in the period of April 2011 to January 2013 where the mothers received one course of corticosteroid prophylaxis and fulfilled the selection criteria. Materials and methods: Perusal of the hospital records was made to gather antenatal information and the details of delivery and the newborn. The patients were divided based on the number of doses of steroids received into three groups. The patients receiving complete steroid prophylaxis was further divided based on the time interval between steroid administration and delivery into five groups: 0 to 7 days, 8 to 14, 15 to 21, 22 to 28, 29 days and beyond. We looked for association between neonatal respiratory outcomes and steroid­delivery intervals using Statistical Package for the Social Sciences version 16 (SPSS, Chicago, USA). Regression model was used to control for the confounding variables. Results: There were 284 women who delivered preterm (up to 34 weeks of gestation) between April 2011 and January 2013 and fulfilled the selection criteria. The babies who received one (48) or no dose of steroids (14) had a higher incidence of respiratory distress than the ones who received a complete dose. This was statistically significant for babies born up to 32 weeks. Among the rest 222 babies who received complete steroid prophylaxis, 138 (62{\%}) of the neonates born were admitted in NICU, respiratory distress was seen in 62 (28{\%}). Eleven (5{\%}) of the babies required intubation and 22 (9{\%}) required surfactant therapy; there were 12 (5{\%}) neonatal deaths. Multivariable logistic regression analysis showed a slightly increased risk of respiratory morbidity with increased interval from administration to delivery (OR–0.87 for 8–14 days, 1.79 for 15–21 days and 0.16 for 22–28 days). Conclusion: The risk of respiratory distress in preterm newborns increases beyond 2 weeks interval between antenatal corticosteroid administration and delivery.",
author = "Shyamala Guruvare and Barnali Basu and Lavanya Rai and Leslie Lewis and Shripad Hebbar and Prashanth Adiga",
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T1 - Relationship of time interval between antenatal corticosteroid administrations to delivery with respiratory distress in preterm newborns

AU - Guruvare, Shyamala

AU - Basu, Barnali

AU - Rai, Lavanya

AU - Lewis, Leslie

AU - Hebbar, Shripad

AU - Adiga, Prashanth

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Objectives: To assess the relationship of time interval between antenatal corticosteroid administration and delivery with respiratory distress in premature newborns. Settings: Tertiary level teaching hospital Population: Preterm deliveries between 28 and 34 weeks in the period of April 2011 to January 2013 where the mothers received one course of corticosteroid prophylaxis and fulfilled the selection criteria. Materials and methods: Perusal of the hospital records was made to gather antenatal information and the details of delivery and the newborn. The patients were divided based on the number of doses of steroids received into three groups. The patients receiving complete steroid prophylaxis was further divided based on the time interval between steroid administration and delivery into five groups: 0 to 7 days, 8 to 14, 15 to 21, 22 to 28, 29 days and beyond. We looked for association between neonatal respiratory outcomes and steroid­delivery intervals using Statistical Package for the Social Sciences version 16 (SPSS, Chicago, USA). Regression model was used to control for the confounding variables. Results: There were 284 women who delivered preterm (up to 34 weeks of gestation) between April 2011 and January 2013 and fulfilled the selection criteria. The babies who received one (48) or no dose of steroids (14) had a higher incidence of respiratory distress than the ones who received a complete dose. This was statistically significant for babies born up to 32 weeks. Among the rest 222 babies who received complete steroid prophylaxis, 138 (62%) of the neonates born were admitted in NICU, respiratory distress was seen in 62 (28%). Eleven (5%) of the babies required intubation and 22 (9%) required surfactant therapy; there were 12 (5%) neonatal deaths. Multivariable logistic regression analysis showed a slightly increased risk of respiratory morbidity with increased interval from administration to delivery (OR–0.87 for 8–14 days, 1.79 for 15–21 days and 0.16 for 22–28 days). Conclusion: The risk of respiratory distress in preterm newborns increases beyond 2 weeks interval between antenatal corticosteroid administration and delivery.

AB - Objectives: To assess the relationship of time interval between antenatal corticosteroid administration and delivery with respiratory distress in premature newborns. Settings: Tertiary level teaching hospital Population: Preterm deliveries between 28 and 34 weeks in the period of April 2011 to January 2013 where the mothers received one course of corticosteroid prophylaxis and fulfilled the selection criteria. Materials and methods: Perusal of the hospital records was made to gather antenatal information and the details of delivery and the newborn. The patients were divided based on the number of doses of steroids received into three groups. The patients receiving complete steroid prophylaxis was further divided based on the time interval between steroid administration and delivery into five groups: 0 to 7 days, 8 to 14, 15 to 21, 22 to 28, 29 days and beyond. We looked for association between neonatal respiratory outcomes and steroid­delivery intervals using Statistical Package for the Social Sciences version 16 (SPSS, Chicago, USA). Regression model was used to control for the confounding variables. Results: There were 284 women who delivered preterm (up to 34 weeks of gestation) between April 2011 and January 2013 and fulfilled the selection criteria. The babies who received one (48) or no dose of steroids (14) had a higher incidence of respiratory distress than the ones who received a complete dose. This was statistically significant for babies born up to 32 weeks. Among the rest 222 babies who received complete steroid prophylaxis, 138 (62%) of the neonates born were admitted in NICU, respiratory distress was seen in 62 (28%). Eleven (5%) of the babies required intubation and 22 (9%) required surfactant therapy; there were 12 (5%) neonatal deaths. Multivariable logistic regression analysis showed a slightly increased risk of respiratory morbidity with increased interval from administration to delivery (OR–0.87 for 8–14 days, 1.79 for 15–21 days and 0.16 for 22–28 days). Conclusion: The risk of respiratory distress in preterm newborns increases beyond 2 weeks interval between antenatal corticosteroid administration and delivery.

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