Release behavior of anticancer drug paclitaxel from tamarind seed polysaccharide galactoxyloglucan

Rashmirekha Sahoo, Soumendra Sahoo, Padma Lochan Nayak

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

In this present research program, mucoadhesive polymer tamarind seed polysaccharide (TSP) "galactoxyloglucan" has been used as the drug carrier for delivery systems of anticancer drug, paclitaxel (PTX) with different concentrations for studying the in-vitro drug delivery systems. The structure characterization of polymer-drug composites were investigated by Fourier Transform Infrared Spectra (FTIR), Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TGA) and X-Ray Diffraction (XRD) Respectively, the drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.

Original languageEnglish
Pages (from-to)197-206
Number of pages10
JournalEuropean Journal of Scientific Research
Volume47
Issue number2
Publication statusPublished - 01-01-2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Mathematics(all)
  • Materials Science(all)
  • Agricultural and Biological Sciences(all)
  • Engineering(all)
  • Earth and Planetary Sciences(all)

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