Repetitive transcranial magnetic stimulation in psychiatry

Biswa Ranjan Mishra, Sukanto Sarkar, Samir Kumar Praharaj, Varun S. Mehta, Shreyansh Diwedi, S. Haque Nizamie

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive and relatively painless tool that has been used to study various cognitive functions as well as to understand the brain-behavior relationship in normal individuals as well as in those with various neuropsychiatric disorders. It has also been used as a therapeutic tool in various neuropsychiatric disorders because of its ability to specifically modulate distinct brain areas. Studies have shown that repeated stimulation at low frequency produces long-lasting inhibition, which is called as long-term depression, whereas repeated high-frequency stimulation can produce excitation through long-term potentiation. This paper reviews the current status of rTMS as an investigative and therapeutic modality in various neuropsychiatric disorders. It has been used to study the cortical and subcortical functions, neural plasticity and brain mapping in normal individuals and in various neuropsychiatric disorders. rTMS has been most promising in the treatment of depression, with an overall milder adverse effect profile compared with electroconvulsive therapy. In other neuropsychiatric disorders such as schizophrenia, mania, epilepsy and substance abuse, it has been found to be useful, although further studies are required to establish therapeutic efficacy. It appears to be ineffective in the treatment of obsessive compulsive disorder. There is a paucity of studies of efficacy and safety of rTMS in pediatric and geriatric population. Although it appears safe, further research is required to optimize its efficacy and reduce the side-effects. Magnetic seizure therapy, which involves producing seizures akin to electroconvulsive therapy, appears to be of comparable efficacy in the treatment of depression with less cognitive adverse effects.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalAnnals of Indian Academy of Neurology
Volume14
Issue number4
DOIs
Publication statusPublished - 01-10-2011

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Transcranial Magnetic Stimulation
Psychiatry
Electroconvulsive Therapy
Depression
Seizures
Therapeutics
Brain Mapping
Neuronal Plasticity
Aptitude
Long-Term Potentiation
Obsessive-Compulsive Disorder
Brain
Bipolar Disorder
Geriatrics
Cognition
Substance-Related Disorders
Epilepsy
Schizophrenia
Pediatrics
Safety

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Mishra, B. R., Sarkar, S., Praharaj, S. K., Mehta, V. S., Diwedi, S., & Haque Nizamie, S. (2011). Repetitive transcranial magnetic stimulation in psychiatry. Annals of Indian Academy of Neurology, 14(4), 245-251. https://doi.org/10.4103/0972-2327.91935
Mishra, Biswa Ranjan ; Sarkar, Sukanto ; Praharaj, Samir Kumar ; Mehta, Varun S. ; Diwedi, Shreyansh ; Haque Nizamie, S. / Repetitive transcranial magnetic stimulation in psychiatry. In: Annals of Indian Academy of Neurology. 2011 ; Vol. 14, No. 4. pp. 245-251.
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Mishra, BR, Sarkar, S, Praharaj, SK, Mehta, VS, Diwedi, S & Haque Nizamie, S 2011, 'Repetitive transcranial magnetic stimulation in psychiatry', Annals of Indian Academy of Neurology, vol. 14, no. 4, pp. 245-251. https://doi.org/10.4103/0972-2327.91935

Repetitive transcranial magnetic stimulation in psychiatry. / Mishra, Biswa Ranjan; Sarkar, Sukanto; Praharaj, Samir Kumar; Mehta, Varun S.; Diwedi, Shreyansh; Haque Nizamie, S.

In: Annals of Indian Academy of Neurology, Vol. 14, No. 4, 01.10.2011, p. 245-251.

Research output: Contribution to journalReview article

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