Replacing 24-h albumin excretion with a shorter collection period in preeclampsia

Savitha Rangasamy, Arun Rao

Research output: Contribution to journalArticle

Abstract

Objectives: To evaluate whether the gold standard of 24-h urinary albumin excretion in preeclamptic women could be substituted by a shorter collection period. Methods: From each woman, three spot, two 12-h, and one 24-h urine samples were collected. For each sample, urine albumin concentrations in milligram per liter were analyzed by the immunoturbidimetric method. The albumin concentrations in the spot and 12-h collections (day and night) were compared with the 24-h urine collection. Results: Albumin concentrations in both 12-h collections were fitted closely with the concentrations of the 24-h collection. The median difference between the 24-h collection and the day collection was 43 mg/L and the correlation coefficient was 0.96 (p < 0.0001). The median difference between the night collection and the 24-h collection was -31 mg/L and the correlation coefficient was 0.98 (p < 0.0001). Conclusion: The gold standard of 24-h urinary albumin concentrations in preeclamptic women can be substituted with a 12-h collection. Spot samples were weaker as compared to the 12-h collection.

Original languageEnglish
Pages (from-to)424-428
Number of pages5
JournalJournal of Obstetrics and Gynecology of India
Volume62
Issue number4
DOIs
Publication statusPublished - 01-08-2012
Externally publishedYes

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Pre-Eclampsia
Albumins
Urine
Urine Specimen Collection

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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abstract = "Objectives: To evaluate whether the gold standard of 24-h urinary albumin excretion in preeclamptic women could be substituted by a shorter collection period. Methods: From each woman, three spot, two 12-h, and one 24-h urine samples were collected. For each sample, urine albumin concentrations in milligram per liter were analyzed by the immunoturbidimetric method. The albumin concentrations in the spot and 12-h collections (day and night) were compared with the 24-h urine collection. Results: Albumin concentrations in both 12-h collections were fitted closely with the concentrations of the 24-h collection. The median difference between the 24-h collection and the day collection was 43 mg/L and the correlation coefficient was 0.96 (p < 0.0001). The median difference between the night collection and the 24-h collection was -31 mg/L and the correlation coefficient was 0.98 (p < 0.0001). Conclusion: The gold standard of 24-h urinary albumin concentrations in preeclamptic women can be substituted with a 12-h collection. Spot samples were weaker as compared to the 12-h collection.",
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Replacing 24-h albumin excretion with a shorter collection period in preeclampsia. / Rangasamy, Savitha; Rao, Arun.

In: Journal of Obstetrics and Gynecology of India, Vol. 62, No. 4, 01.08.2012, p. 424-428.

Research output: Contribution to journalArticle

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