Reproductive toxicity of sodium valproate in male rats

Laxminarayana Bairy, Vijay Paul, Yeshwanth Karkal Rao

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: To assess the effects of sodium valproate on rat sperm morphology, sperm count, motility, and histopathological changes in testis. Materials and Methods: Male Wistar rats (12 week old) were treated with sodium valpraote and sacrificed at the end of 2nd, 4th, 5th, 7th, 10thand 15thweek after the last exposure to sodium valproate. Epididymal sperm count, sperm motility, sperm morphology, and histopathology of testes were analyzed. Results: Sperm count and sperm motility were decreased significantly by sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. A histopathological study revealed that sodium valproate had caused sloughing of epithelial cells in testes. Conclusion: Sodium valproate causes reversible change in sperm motility, sperm count, morphology, and cytoarchitecture of testes.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalIndian Journal of Pharmacology
Volume42
Issue number2
DOIs
Publication statusPublished - 01-03-2010

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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