TY - JOUR
T1 - Repulsive surfaces and lamellar lubrication of synovial joints
AU - Pawlak, Zenon
AU - Yusuf, Kehinde Q.
AU - Pai, Raghuvir
AU - Urbaniak, Wieslaw
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Surface-active phospholipid (SAPL) secreted in the synovial joint plays an important role in cartilage integrity. In healthy joints, phospholipid multibilayers coat the cartilage surface, providing boundary lamellar-repulsive hydration lubrication. Current mechanism for lubrication of synovial joints, as well as the physical and chemical nature of the cartilage surface is discussed. Friction between phospholipid (PL) bilayers attached to cartilage surfaces is considered including a discussion on the recent observation of an extreme friction reduction as a consequence of a less charged hydrophilic cartilage surface. It is proposed that the highly efficient lubrication occurring in natural joints arises from the presence of negatively charged cartilage surfaces. The lamellar-repulsive mechanisms for the reduction of friction is supported by phospholipid lamellar phases and charged macromolecules residing between contacting cartilage surfaces at pH ∼7.4.
AB - Surface-active phospholipid (SAPL) secreted in the synovial joint plays an important role in cartilage integrity. In healthy joints, phospholipid multibilayers coat the cartilage surface, providing boundary lamellar-repulsive hydration lubrication. Current mechanism for lubrication of synovial joints, as well as the physical and chemical nature of the cartilage surface is discussed. Friction between phospholipid (PL) bilayers attached to cartilage surfaces is considered including a discussion on the recent observation of an extreme friction reduction as a consequence of a less charged hydrophilic cartilage surface. It is proposed that the highly efficient lubrication occurring in natural joints arises from the presence of negatively charged cartilage surfaces. The lamellar-repulsive mechanisms for the reduction of friction is supported by phospholipid lamellar phases and charged macromolecules residing between contacting cartilage surfaces at pH ∼7.4.
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U2 - 10.1016/j.abb.2017.05.009
DO - 10.1016/j.abb.2017.05.009
M3 - Article
C2 - 28528195
AN - SCOPUS:85019588191
SN - 0003-9861
VL - 623-624
SP - 42
EP - 48
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
ER -