Response of mouse sarcoma- 180 to bleomycin in combination with radiation and hyperthermia

P. Uma Devi, B. S. Satish Rao

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The response of a transplantable mouse tumor, S-180, grown intradermally in inbred Balb/c mice, to bleomycin (BLM), irradiation (RT) and hyperthermia (HT) was studied by observing tumor growth changes up to 120 days after treatment. BLM, at 20 mg/kg body weight, and 10 Gy gamma radiation individually produced identical tumor cure, while hyperthermia at 42°C, 60' or 43°C, 30' resulted in a higher tumor response. Treatment with 43°C, 30' after BLM was more effective than hyperthermia after radiation in effecting tumor cure as well as in inducing regrowth delay. In the drug + HT combination the low drug dose was almost equal in effect as the higher drug dose when followed by 43°C, 30'. Combining the three modalities resulted in 100% tumor cure without any local recurrence during the observation period. The micronucleus study 24 h after treatment indicated enhanced cytogenetic damage by the combination treatments.

Original languageEnglish
Pages (from-to)601-607
Number of pages7
JournalStrahlentherapie und Onkologie
Volume169
Issue number10
Publication statusPublished - 1993

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Sarcoma 180
Fever
Radiation
Bleomycin
Neoplasms
Radiation Dosage
Gamma Rays
Drug Combinations
Cytogenetics
Pharmaceutical Preparations
indium-bleomycin
Body Weight
Observation
Recurrence
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "The response of a transplantable mouse tumor, S-180, grown intradermally in inbred Balb/c mice, to bleomycin (BLM), irradiation (RT) and hyperthermia (HT) was studied by observing tumor growth changes up to 120 days after treatment. BLM, at 20 mg/kg body weight, and 10 Gy gamma radiation individually produced identical tumor cure, while hyperthermia at 42°C, 60' or 43°C, 30' resulted in a higher tumor response. Treatment with 43°C, 30' after BLM was more effective than hyperthermia after radiation in effecting tumor cure as well as in inducing regrowth delay. In the drug + HT combination the low drug dose was almost equal in effect as the higher drug dose when followed by 43°C, 30'. Combining the three modalities resulted in 100{\%} tumor cure without any local recurrence during the observation period. The micronucleus study 24 h after treatment indicated enhanced cytogenetic damage by the combination treatments.",
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Response of mouse sarcoma- 180 to bleomycin in combination with radiation and hyperthermia. / Uma Devi, P.; Satish Rao, B. S.

In: Strahlentherapie und Onkologie, Vol. 169, No. 10, 1993, p. 601-607.

Research output: Contribution to journalArticle

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