Reversal of natural resistance to bouvardin (NSC 259968) in sarcoma 180 cells in vitro and in vivo by verapamil

M. P. Chitnis, R. S. Menon, V. S. Basrur, M. K. Adwankar, K. Satyamoorthy

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    Abstract

    Reversal of natural resistance to bouvardin (NSC 259968) has been attained in vitro and in vivo, by the calcium influx blocker verapamil in sarcoma 180 cells insensitive to bouvardin. Verapamil increased the in vitro lethality of the tumor cells following exposure with cells for 1 and 3 h as a result of the cytotoxic effect of bouvardin. Similar results were observed in vivo when the tumor cells were exposed to verapamil and then treated with bouvardin, showing a significant percent increase in the lifespan to 30% and 45%. This suggested that this calcium channel blocker had interacted with tumor cell membrane to modulate the response of the cells, and make them more amenable to the drug action.

    Original languageEnglish
    Pages (from-to)221-224
    Number of pages4
    JournalJournal of Cancer Research and Clinical Oncology
    Volume110
    Issue number3
    DOIs
    Publication statusPublished - 12-1985

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    All Science Journal Classification (ASJC) codes

    • Oncology
    • Cancer Research

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