Risk of oral cancer associated with gutka and other tobacco products

A hospital-based case-control study

Sandeep Mahapatra, Ramachandra Kamath, Bharatesh K. Shetty, V. Binu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Although tobacco deaths rarely make headlines, tobacco kills one person every six seconds. Tobacco kills a third to half of all people who use it, on average 15 years prematurely. Aim of the Study: To study the risk of oral cancer associated with gutka consumption and other tobacco products. Objective: (1) To find the association between gutka consumption and oral cancer. (2) To study the association between oral cancer and other tobacco products. Methodology: A case-control study of 134 cases and 268 controls, over a period of 5 months, from March 2013 to July 2013, was carried out at the Kasturba medical hospital in Manipal, India. The participants were personally interviewed by the investigator using a structured questionnaire on consumption of tobacco, poly-ingredient dip products, alcohol, dietary practices, oral hygiene practices and demographic status. Results: Univariate logistic regression followed by multivariate logistic regression was done for identifying the risk factors and adjusted for the confounding variables. Analysis showed that gutka (<0.001, OR = 5.1 95% CI = 2.0-10.3), chewing tobacco (P < 0.001, OR = 6.0 95% CI = 2.3-15.7), supari (P < 0.001, OR = 11.4 95% CI = 3.4,38.2), betel quid (P < 0.001, OR = 6.4 95% CI = 2.6-15.5), bidi (P < 0.05, OR = 2.3 95% CI = 1.1-4.8) and alcohol (P < 0.001, OR = 3.7 95%CI = 1.8-7.5) had strong association with oral cancer upon adjustment. Conclusion: The study provided strong evidence that gutka, supari, chewing tobacco, betel quid, bidi and alcohol are independent risk factors for oral cancer.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalJournal of Cancer Research and Therapeutics
Volume11
Issue number1
DOIs
Publication statusPublished - 01-01-2015

Fingerprint

Mouth Neoplasms
Tobacco Products
Case-Control Studies
Tobacco
Smokeless Tobacco
Alcohols
Logistic Models
Social Adjustment
Confounding Factors (Epidemiology)
Oral Hygiene
Tobacco Use
India
Research Personnel
Demography

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Mahapatra, Sandeep ; Kamath, Ramachandra ; Shetty, Bharatesh K. ; Binu, V. / Risk of oral cancer associated with gutka and other tobacco products : A hospital-based case-control study. In: Journal of Cancer Research and Therapeutics. 2015 ; Vol. 11, No. 1. pp. 199-203.
@article{5ee7c682dbfe435ea17fdb8a2d0c81c2,
title = "Risk of oral cancer associated with gutka and other tobacco products: A hospital-based case-control study",
abstract = "Background: Although tobacco deaths rarely make headlines, tobacco kills one person every six seconds. Tobacco kills a third to half of all people who use it, on average 15 years prematurely. Aim of the Study: To study the risk of oral cancer associated with gutka consumption and other tobacco products. Objective: (1) To find the association between gutka consumption and oral cancer. (2) To study the association between oral cancer and other tobacco products. Methodology: A case-control study of 134 cases and 268 controls, over a period of 5 months, from March 2013 to July 2013, was carried out at the Kasturba medical hospital in Manipal, India. The participants were personally interviewed by the investigator using a structured questionnaire on consumption of tobacco, poly-ingredient dip products, alcohol, dietary practices, oral hygiene practices and demographic status. Results: Univariate logistic regression followed by multivariate logistic regression was done for identifying the risk factors and adjusted for the confounding variables. Analysis showed that gutka (<0.001, OR = 5.1 95{\%} CI = 2.0-10.3), chewing tobacco (P < 0.001, OR = 6.0 95{\%} CI = 2.3-15.7), supari (P < 0.001, OR = 11.4 95{\%} CI = 3.4,38.2), betel quid (P < 0.001, OR = 6.4 95{\%} CI = 2.6-15.5), bidi (P < 0.05, OR = 2.3 95{\%} CI = 1.1-4.8) and alcohol (P < 0.001, OR = 3.7 95{\%}CI = 1.8-7.5) had strong association with oral cancer upon adjustment. Conclusion: The study provided strong evidence that gutka, supari, chewing tobacco, betel quid, bidi and alcohol are independent risk factors for oral cancer.",
author = "Sandeep Mahapatra and Ramachandra Kamath and Shetty, {Bharatesh K.} and V. Binu",
year = "2015",
month = "1",
day = "1",
doi = "10.4103/0973-1482.143332",
language = "English",
volume = "11",
pages = "199--203",
journal = "Journal of Cancer Research and Therapeutics",
issn = "0973-1482",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Risk of oral cancer associated with gutka and other tobacco products : A hospital-based case-control study. / Mahapatra, Sandeep; Kamath, Ramachandra; Shetty, Bharatesh K.; Binu, V.

In: Journal of Cancer Research and Therapeutics, Vol. 11, No. 1, 01.01.2015, p. 199-203.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Risk of oral cancer associated with gutka and other tobacco products

T2 - A hospital-based case-control study

AU - Mahapatra, Sandeep

AU - Kamath, Ramachandra

AU - Shetty, Bharatesh K.

AU - Binu, V.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Although tobacco deaths rarely make headlines, tobacco kills one person every six seconds. Tobacco kills a third to half of all people who use it, on average 15 years prematurely. Aim of the Study: To study the risk of oral cancer associated with gutka consumption and other tobacco products. Objective: (1) To find the association between gutka consumption and oral cancer. (2) To study the association between oral cancer and other tobacco products. Methodology: A case-control study of 134 cases and 268 controls, over a period of 5 months, from March 2013 to July 2013, was carried out at the Kasturba medical hospital in Manipal, India. The participants were personally interviewed by the investigator using a structured questionnaire on consumption of tobacco, poly-ingredient dip products, alcohol, dietary practices, oral hygiene practices and demographic status. Results: Univariate logistic regression followed by multivariate logistic regression was done for identifying the risk factors and adjusted for the confounding variables. Analysis showed that gutka (<0.001, OR = 5.1 95% CI = 2.0-10.3), chewing tobacco (P < 0.001, OR = 6.0 95% CI = 2.3-15.7), supari (P < 0.001, OR = 11.4 95% CI = 3.4,38.2), betel quid (P < 0.001, OR = 6.4 95% CI = 2.6-15.5), bidi (P < 0.05, OR = 2.3 95% CI = 1.1-4.8) and alcohol (P < 0.001, OR = 3.7 95%CI = 1.8-7.5) had strong association with oral cancer upon adjustment. Conclusion: The study provided strong evidence that gutka, supari, chewing tobacco, betel quid, bidi and alcohol are independent risk factors for oral cancer.

AB - Background: Although tobacco deaths rarely make headlines, tobacco kills one person every six seconds. Tobacco kills a third to half of all people who use it, on average 15 years prematurely. Aim of the Study: To study the risk of oral cancer associated with gutka consumption and other tobacco products. Objective: (1) To find the association between gutka consumption and oral cancer. (2) To study the association between oral cancer and other tobacco products. Methodology: A case-control study of 134 cases and 268 controls, over a period of 5 months, from March 2013 to July 2013, was carried out at the Kasturba medical hospital in Manipal, India. The participants were personally interviewed by the investigator using a structured questionnaire on consumption of tobacco, poly-ingredient dip products, alcohol, dietary practices, oral hygiene practices and demographic status. Results: Univariate logistic regression followed by multivariate logistic regression was done for identifying the risk factors and adjusted for the confounding variables. Analysis showed that gutka (<0.001, OR = 5.1 95% CI = 2.0-10.3), chewing tobacco (P < 0.001, OR = 6.0 95% CI = 2.3-15.7), supari (P < 0.001, OR = 11.4 95% CI = 3.4,38.2), betel quid (P < 0.001, OR = 6.4 95% CI = 2.6-15.5), bidi (P < 0.05, OR = 2.3 95% CI = 1.1-4.8) and alcohol (P < 0.001, OR = 3.7 95%CI = 1.8-7.5) had strong association with oral cancer upon adjustment. Conclusion: The study provided strong evidence that gutka, supari, chewing tobacco, betel quid, bidi and alcohol are independent risk factors for oral cancer.

UR - http://www.scopus.com/inward/record.url?scp=84928620137&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928620137&partnerID=8YFLogxK

U2 - 10.4103/0973-1482.143332

DO - 10.4103/0973-1482.143332

M3 - Article

VL - 11

SP - 199

EP - 203

JO - Journal of Cancer Research and Therapeutics

JF - Journal of Cancer Research and Therapeutics

SN - 0973-1482

IS - 1

ER -