Abstract

Maintaining the glucose concentration in normoglycemic range in Type 1 diabetic patients is challenging. In this study, H∞ control is applied for the insulin delivery to prevent the hyperglycemic levels in a Type 1 diabetic patient. From a control theory point of view, the blood glucose regulation problem is reformulated as a tracking one. A glucose tolerance curve (GTC) validated from several healthy subjects is used as reference signal. A non-linear compartmental model is linearised around nominal condition and reduced for controller synthesis. The design of H∞ controller was carried out using Riccati equation. The performance of the controllers was studied by implementing them into the non-linear model. Sensitivity and complementary sensitivity functions show the nominal and robust performance of the closed loop system.

Original languageEnglish
Pages (from-to)289-306
Number of pages18
JournalInternational Journal of Medical Engineering and Informatics
Volume2
Issue number3
DOIs
Publication statusPublished - 09-2010

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All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Health Informatics

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