Role of antioxidant enzymes in brain tumours

Gayathri M. Rao, Ashalatha V. Rao, Annaswamy Raja, Suryanarayana Rao, Anjali Rao

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Erythrocyte antioxidant enzymes were analysed in 100 patients with intracranial neoplasm and in 47 controls. There was a significant decrease in RBC glutathione reductase (GRx) and superoxide dismutase (SOD) activity in most types of brain tumor cases. Patients with acoustic neurinoma showed a significant reduction in selenium-dependent glutathione peroxidase (Se-GPx) activity. A decrease in catalase (CT) activity was seen in most of the brain tumor patients but remained statistically insignificant when compared to controls. A significant increase in plasma ceruloplasmin concentration was observed in patients with glioma. These enzymes were also studied in 27 post-treatment cases. GRx activity returned to normal levels in these patients. RBC SOD and plasma ceruloplasmin levels showed a tendency to return to normal. Hence, a marked decrease in the antioxidant enzymes may have a role in the genesis of considerable oxidative stress in patients with brain tumors. Copyright (C) 2000.

Original languageEnglish
Pages (from-to)203-212
Number of pages10
JournalClinica Chimica Acta
Volume296
Issue number1-2
DOIs
Publication statusPublished - 01-06-2000

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Brain Neoplasms
Tumors
Brain
Ceruloplasmin
Antioxidants
Superoxide Dismutase
Enzymes
Plasmas
Oxidative stress
Glutathione Reductase
Selenium
Glutathione Peroxidase
Catalase
Acoustics
Acoustic Neuroma
Glioma
Oxidative Stress
Erythrocytes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Rao, Gayathri M. ; Rao, Ashalatha V. ; Raja, Annaswamy ; Rao, Suryanarayana ; Rao, Anjali. / Role of antioxidant enzymes in brain tumours. In: Clinica Chimica Acta. 2000 ; Vol. 296, No. 1-2. pp. 203-212.
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Rao, GM, Rao, AV, Raja, A, Rao, S & Rao, A 2000, 'Role of antioxidant enzymes in brain tumours', Clinica Chimica Acta, vol. 296, no. 1-2, pp. 203-212. https://doi.org/10.1016/S0009-8981(00)00219-9

Role of antioxidant enzymes in brain tumours. / Rao, Gayathri M.; Rao, Ashalatha V.; Raja, Annaswamy; Rao, Suryanarayana; Rao, Anjali.

In: Clinica Chimica Acta, Vol. 296, No. 1-2, 01.06.2000, p. 203-212.

Research output: Contribution to journalArticle

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