Role of components in the formation of self-microemulsifying drug delivery systems

A. K. Gurram, P. B. Deshpande, S. S. Kar, Usha Nayak, N. Udupa, M. S. Reddy

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

Pharmaceutical research is focused in designing novel drug delivery systems to improve the bioavailability of poorly water soluble drugs. Self-microemulsifying drug delivery systems, one among the lipid-based dosage forms were proven to be promising in improving the oral bioavailability of such drugs by enhancing solubility, permeability and avoiding first-pass metabolism via enhanced lymphatic transport. Further, they have been successful in avoiding both inter and intra individual variations as well as the dose disproportionality. Aqueous insoluble drugs, in general, show greater solubility in lipid based excipients, and hence they are formulated as lipid based drug delivery systems. The extent of solubility of a hydrophobic drug in lipid excipients i.e. oil, surfactant and co-surfactant (components of self-microemulsifying drug delivery systems) greatly affects the drug loading and in producing stable self-microemulsifying drug delivery systems. The present review highlighted the influence of physicochemical factors and structural features of the hydrophobic drug on its solubility in lipid excipients and an attempt was made to explore the role of each component of self-microemulsifying drug delivery systems in the formation of stable microemulsion upon dilution.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalIndian Journal of Pharmaceutical Sciences
Volume77
Issue number3
Publication statusPublished - 01-05-2015

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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