Role of copper and vascular endothelial growth factor (VEGF) on endometrial angiogenesis

Yousef Rezaei Chianeh, Pragna Rao

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The formation of new blood vessels is the initial step in neovascularisation. The first stage in angiogenesis is the activation of endothelial cells. Copper ions stimulate proliferation and immigration of endothelial cells. It has been shown that serum copper concentration increases as the cancer disease progresses and correlates with tumour incidence and burden. Copper ions also activate several proangiogenic factors, e.g., vascular endothelial growth factor, basic fibroblast growth factor, and interleukin 1. This review concerns a brief introduction into the basics of blood vessel development as well as the regulatory mechanisms of this process. The role of copper ions in angiogenesis is discussed.

Original languageEnglish
Pages (from-to)6-17
Number of pages12
JournalJournal of Krishna Institute of Medical Sciences University
Volume2
Issue number2
Publication statusPublished - 2013

Fingerprint

Vascular Endothelial Growth Factor A
Copper
Ions
Blood Vessels
Endothelial Cells
Fibroblast Growth Factor 1
Emigration and Immigration
Fibroblast Growth Factor 2
Tumor Burden
Interleukin-1
Incidence
Serum
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Role of copper and vascular endothelial growth factor (VEGF) on endometrial angiogenesis",
abstract = "The formation of new blood vessels is the initial step in neovascularisation. The first stage in angiogenesis is the activation of endothelial cells. Copper ions stimulate proliferation and immigration of endothelial cells. It has been shown that serum copper concentration increases as the cancer disease progresses and correlates with tumour incidence and burden. Copper ions also activate several proangiogenic factors, e.g., vascular endothelial growth factor, basic fibroblast growth factor, and interleukin 1. This review concerns a brief introduction into the basics of blood vessel development as well as the regulatory mechanisms of this process. The role of copper ions in angiogenesis is discussed.",
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Role of copper and vascular endothelial growth factor (VEGF) on endometrial angiogenesis. / Chianeh, Yousef Rezaei; Rao, Pragna.

In: Journal of Krishna Institute of Medical Sciences University, Vol. 2, No. 2, 2013, p. 6-17.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Role of copper and vascular endothelial growth factor (VEGF) on endometrial angiogenesis

AU - Chianeh, Yousef Rezaei

AU - Rao, Pragna

PY - 2013

Y1 - 2013

N2 - The formation of new blood vessels is the initial step in neovascularisation. The first stage in angiogenesis is the activation of endothelial cells. Copper ions stimulate proliferation and immigration of endothelial cells. It has been shown that serum copper concentration increases as the cancer disease progresses and correlates with tumour incidence and burden. Copper ions also activate several proangiogenic factors, e.g., vascular endothelial growth factor, basic fibroblast growth factor, and interleukin 1. This review concerns a brief introduction into the basics of blood vessel development as well as the regulatory mechanisms of this process. The role of copper ions in angiogenesis is discussed.

AB - The formation of new blood vessels is the initial step in neovascularisation. The first stage in angiogenesis is the activation of endothelial cells. Copper ions stimulate proliferation and immigration of endothelial cells. It has been shown that serum copper concentration increases as the cancer disease progresses and correlates with tumour incidence and burden. Copper ions also activate several proangiogenic factors, e.g., vascular endothelial growth factor, basic fibroblast growth factor, and interleukin 1. This review concerns a brief introduction into the basics of blood vessel development as well as the regulatory mechanisms of this process. The role of copper ions in angiogenesis is discussed.

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M3 - Review article

VL - 2

SP - 6

EP - 17

JO - Journal of Krishna Institute of Medical Sciences University

JF - Journal of Krishna Institute of Medical Sciences University

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