Role of deformation imaging in left ventricular non-compaction and hypertrophic cardiomyopathy: an Indian perspective

A. J. Ashwal, Sudhakar Rao Mugula, Jyothi Samanth, Ganesh Paramasivam, Krishnananda Nayak, R. Padmakumar

Research output: Contribution to journalArticle

Abstract

Background: Speckle tracking echocardiography (STE) has emerged as a novel feasible tool for the assessment of left ventricular rotational parameters. Since hypertrophic cardiomyopathy(HCM) shares morphologic features with left ventricular non-compaction (LVNC), we used this imaging modality to compare rotational mechanics between these two entities. Results: We compared global and regional LV function and rotational mechanics between LVNC, HCM, and healthy subjects using STE. Longitudinal strain and torsion were obtained from echocardiographic images from parasternal short axis as well as standard LV apical views. Twelve patients with LVNC [mean age 46.12 ± 14.66 years; median 47.5 IQR (39.25–58.5) years] were compared with 18 HCM patients [mean age 49.48± 17.22 years; median 56 IQR (33–65) years] and 18 healthy subjects [mean age: 51.50± 12.51 years; median 51(45.75-58) years]. LVNC group showed a significantly reduced longitudinal strain at the apical region compared to HCM group (− 12.18 ± 6.25 vs − 18.37 ± 3.67; P < 0.05). Rigid body rotation(RBR) was found in 50% of patients whereas the other half had a normal rotation at the apex and the base. Among the patients with RBR, all patients had a uniform counterclockwise rotation. Conclusion: Longitudinal strain was impaired in both the forms of cardiomyopathy; however, LVNC showed a more significant reduction in the apical region compared to patients with HCM suggesting a development abnormality in these regions. A reduction in left ventricular torsion was specifically noted among patients with LVNC with a uniform anticlockwise rotation of LV base and apex.

Original languageEnglish
Article number6
JournalEgyptian Heart Journal
Volume72
Issue number1
DOIs
Publication statusPublished - 01-12-2020

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Hypertrophic Cardiomyopathy
Mechanics
Echocardiography
Healthy Volunteers
Cardiomyopathies

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Role of deformation imaging in left ventricular non-compaction and hypertrophic cardiomyopathy: an Indian perspective",
abstract = "Background: Speckle tracking echocardiography (STE) has emerged as a novel feasible tool for the assessment of left ventricular rotational parameters. Since hypertrophic cardiomyopathy(HCM) shares morphologic features with left ventricular non-compaction (LVNC), we used this imaging modality to compare rotational mechanics between these two entities. Results: We compared global and regional LV function and rotational mechanics between LVNC, HCM, and healthy subjects using STE. Longitudinal strain and torsion were obtained from echocardiographic images from parasternal short axis as well as standard LV apical views. Twelve patients with LVNC [mean age 46.12 ± 14.66 years; median 47.5 IQR (39.25–58.5) years] were compared with 18 HCM patients [mean age 49.48± 17.22 years; median 56 IQR (33–65) years] and 18 healthy subjects [mean age: 51.50± 12.51 years; median 51(45.75-58) years]. LVNC group showed a significantly reduced longitudinal strain at the apical region compared to HCM group (− 12.18 ± 6.25 vs − 18.37 ± 3.67; P < 0.05). Rigid body rotation(RBR) was found in 50{\%} of patients whereas the other half had a normal rotation at the apex and the base. Among the patients with RBR, all patients had a uniform counterclockwise rotation. Conclusion: Longitudinal strain was impaired in both the forms of cardiomyopathy; however, LVNC showed a more significant reduction in the apical region compared to patients with HCM suggesting a development abnormality in these regions. A reduction in left ventricular torsion was specifically noted among patients with LVNC with a uniform anticlockwise rotation of LV base and apex.",
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Role of deformation imaging in left ventricular non-compaction and hypertrophic cardiomyopathy : an Indian perspective. / Ashwal, A. J.; Mugula, Sudhakar Rao; Samanth, Jyothi; Paramasivam, Ganesh; Nayak, Krishnananda; Padmakumar, R.

In: Egyptian Heart Journal, Vol. 72, No. 1, 6, 01.12.2020.

Research output: Contribution to journalArticle

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T1 - Role of deformation imaging in left ventricular non-compaction and hypertrophic cardiomyopathy

T2 - an Indian perspective

AU - Ashwal, A. J.

AU - Mugula, Sudhakar Rao

AU - Samanth, Jyothi

AU - Paramasivam, Ganesh

AU - Nayak, Krishnananda

AU - Padmakumar, R.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Background: Speckle tracking echocardiography (STE) has emerged as a novel feasible tool for the assessment of left ventricular rotational parameters. Since hypertrophic cardiomyopathy(HCM) shares morphologic features with left ventricular non-compaction (LVNC), we used this imaging modality to compare rotational mechanics between these two entities. Results: We compared global and regional LV function and rotational mechanics between LVNC, HCM, and healthy subjects using STE. Longitudinal strain and torsion were obtained from echocardiographic images from parasternal short axis as well as standard LV apical views. Twelve patients with LVNC [mean age 46.12 ± 14.66 years; median 47.5 IQR (39.25–58.5) years] were compared with 18 HCM patients [mean age 49.48± 17.22 years; median 56 IQR (33–65) years] and 18 healthy subjects [mean age: 51.50± 12.51 years; median 51(45.75-58) years]. LVNC group showed a significantly reduced longitudinal strain at the apical region compared to HCM group (− 12.18 ± 6.25 vs − 18.37 ± 3.67; P < 0.05). Rigid body rotation(RBR) was found in 50% of patients whereas the other half had a normal rotation at the apex and the base. Among the patients with RBR, all patients had a uniform counterclockwise rotation. Conclusion: Longitudinal strain was impaired in both the forms of cardiomyopathy; however, LVNC showed a more significant reduction in the apical region compared to patients with HCM suggesting a development abnormality in these regions. A reduction in left ventricular torsion was specifically noted among patients with LVNC with a uniform anticlockwise rotation of LV base and apex.

AB - Background: Speckle tracking echocardiography (STE) has emerged as a novel feasible tool for the assessment of left ventricular rotational parameters. Since hypertrophic cardiomyopathy(HCM) shares morphologic features with left ventricular non-compaction (LVNC), we used this imaging modality to compare rotational mechanics between these two entities. Results: We compared global and regional LV function and rotational mechanics between LVNC, HCM, and healthy subjects using STE. Longitudinal strain and torsion were obtained from echocardiographic images from parasternal short axis as well as standard LV apical views. Twelve patients with LVNC [mean age 46.12 ± 14.66 years; median 47.5 IQR (39.25–58.5) years] were compared with 18 HCM patients [mean age 49.48± 17.22 years; median 56 IQR (33–65) years] and 18 healthy subjects [mean age: 51.50± 12.51 years; median 51(45.75-58) years]. LVNC group showed a significantly reduced longitudinal strain at the apical region compared to HCM group (− 12.18 ± 6.25 vs − 18.37 ± 3.67; P < 0.05). Rigid body rotation(RBR) was found in 50% of patients whereas the other half had a normal rotation at the apex and the base. Among the patients with RBR, all patients had a uniform counterclockwise rotation. Conclusion: Longitudinal strain was impaired in both the forms of cardiomyopathy; however, LVNC showed a more significant reduction in the apical region compared to patients with HCM suggesting a development abnormality in these regions. A reduction in left ventricular torsion was specifically noted among patients with LVNC with a uniform anticlockwise rotation of LV base and apex.

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U2 - 10.1186/s43044-020-0041-z

DO - 10.1186/s43044-020-0041-z

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