Role of glutamine deamidation in neurodegenerative diseases associated with triplet repeat expansions: A hypothesis

Qurratulain Hasan, Ravindra Varma Alluri, Pragna Rao, Yog Raj Ahuja

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The pathological expansion of unstable trinucleotide repeats is known to cause neurodegenerative diseases. Trinucleotide repeat expansions might prove to be pathological through a variety of mechanisms, including alteration of DNA structure, transcription, RNA-protein interaction, and altered protein conformations/interactions. Deamidation of human proteins have been shown to regulate some time-dependent biological processes such as development and aging. In this paper we hypothesize the possible role of glutamine deamidation as a signaling event in the pathogenesis of neurodegenerative diseases associated with triplet repeat expansion.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalJournal of Molecular Neuroscience
Volume29
Issue number1
DOIs
Publication statusPublished - 05-2006

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry
  • Genetics

Cite this