Role of miRNA clusters in epithelial to mesenchymal transition in cancer

Vaibhav Shukla, Divya Adiga, Padacherri Vethil Jishnu, Vinay Koshy Varghese, Kapaettu Satyamoorthy, Shama Prasada Kabekkodu

Research output: Contribution to journalArticle

Abstract

Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.

Original languageEnglish
Pages (from-to)48-78
Number of pages31
JournalFrontiers in bioscience (Elite edition)
Volume12
DOIs
Publication statusPublished - 01-01-2020

Fingerprint

Epithelial-Mesenchymal Transition
MicroRNAs
Neoplasms
Untranslated RNA
Biological Phenomena
Gastropoda
Gene expression
Transcription Factors
Genes
Chemical activation
Up-Regulation
Down-Regulation
Epithelial Cells
Messenger RNA
Gene Expression

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Shukla, Vaibhav ; Adiga, Divya ; Jishnu, Padacherri Vethil ; Varghese, Vinay Koshy ; Satyamoorthy, Kapaettu ; Kabekkodu, Shama Prasada. / Role of miRNA clusters in epithelial to mesenchymal transition in cancer. In: Frontiers in bioscience (Elite edition). 2020 ; Vol. 12. pp. 48-78.
@article{38b64dbfaccf42ec9871004bfc1783b8,
title = "Role of miRNA clusters in epithelial to mesenchymal transition in cancer",
abstract = "Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.",
author = "Vaibhav Shukla and Divya Adiga and Jishnu, {Padacherri Vethil} and Varghese, {Vinay Koshy} and Kapaettu Satyamoorthy and Kabekkodu, {Shama Prasada}",
year = "2020",
month = "1",
day = "1",
doi = "10.2741/e857",
language = "English",
volume = "12",
pages = "48--78",
journal = "Frontiers in Bioscience - Elite",
issn = "1945-0494",
publisher = "Frontiers in Bioscience",

}

Role of miRNA clusters in epithelial to mesenchymal transition in cancer. / Shukla, Vaibhav; Adiga, Divya; Jishnu, Padacherri Vethil; Varghese, Vinay Koshy; Satyamoorthy, Kapaettu; Kabekkodu, Shama Prasada.

In: Frontiers in bioscience (Elite edition), Vol. 12, 01.01.2020, p. 48-78.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of miRNA clusters in epithelial to mesenchymal transition in cancer

AU - Shukla, Vaibhav

AU - Adiga, Divya

AU - Jishnu, Padacherri Vethil

AU - Varghese, Vinay Koshy

AU - Satyamoorthy, Kapaettu

AU - Kabekkodu, Shama Prasada

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.

AB - Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.

UR - http://www.scopus.com/inward/record.url?scp=85072933208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072933208&partnerID=8YFLogxK

U2 - 10.2741/e857

DO - 10.2741/e857

M3 - Article

C2 - 31585869

AN - SCOPUS:85072933208

VL - 12

SP - 48

EP - 78

JO - Frontiers in Bioscience - Elite

JF - Frontiers in Bioscience - Elite

SN - 1945-0494

ER -