Role of Shear Wave Elastography in the Assessment of Fibrosis in Chronic Liver Disease

Sravya Bellamkonda, Samir M. Paruthikunnan, Rajgopal V. Kadavigere, Smiti Sripathi

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the diagnostic performance of shear wave elastography in the estimation of fibrosis in patients with chronic liver disease by using biopsy and/or serum markers as reference standard. Materials and methods: 100 patients underwent point quantification-shear wave elastography, for whom noninvasive serum fibrosis indices like APRI, FIB-4, and King’s score were calculated. The receiver-operator characteristic (ROC) curve analysis was performed. Results: The shear wave elastography measurements showed moderate agreement with APRI, FIB-4, and fair agreement with King’s score. The AUROC for differentiating F0-F1, F2-F3, F2-F3, and F4 are 0.873 and 0.504 respectively using APRI as reference standard. The cutoff values derived for differentiating F0-F1 and F2-F3 was 7.07 and for differentiating F2-F3 and F4 was 11.94. Conclusion: The diagnostic performance of shear wave elastography is comparable with that of serum fibrosis indices APRI and FIB-4.

Original languageEnglish
Pages (from-to)460-465
Number of pages6
JournalJournal of Diagnostic Medical Sonography
Volume34
Issue number6
DOIs
Publication statusPublished - 01-11-2018

Fingerprint

Elasticity Imaging Techniques
Liver Diseases
Fibrosis
Chronic Disease
Serum
Biomarkers
Biopsy
beryllium trifluoride

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Bellamkonda, Sravya ; Paruthikunnan, Samir M. ; Kadavigere, Rajgopal V. ; Sripathi, Smiti. / Role of Shear Wave Elastography in the Assessment of Fibrosis in Chronic Liver Disease. In: Journal of Diagnostic Medical Sonography. 2018 ; Vol. 34, No. 6. pp. 460-465.
@article{77c4b94ad6f14dc9b841fbaf8a6c5407,
title = "Role of Shear Wave Elastography in the Assessment of Fibrosis in Chronic Liver Disease",
abstract = "Objective: To evaluate the diagnostic performance of shear wave elastography in the estimation of fibrosis in patients with chronic liver disease by using biopsy and/or serum markers as reference standard. Materials and methods: 100 patients underwent point quantification-shear wave elastography, for whom noninvasive serum fibrosis indices like APRI, FIB-4, and King’s score were calculated. The receiver-operator characteristic (ROC) curve analysis was performed. Results: The shear wave elastography measurements showed moderate agreement with APRI, FIB-4, and fair agreement with King’s score. The AUROC for differentiating F0-F1, F2-F3, F2-F3, and F4 are 0.873 and 0.504 respectively using APRI as reference standard. The cutoff values derived for differentiating F0-F1 and F2-F3 was 7.07 and for differentiating F2-F3 and F4 was 11.94. Conclusion: The diagnostic performance of shear wave elastography is comparable with that of serum fibrosis indices APRI and FIB-4.",
author = "Sravya Bellamkonda and Paruthikunnan, {Samir M.} and Kadavigere, {Rajgopal V.} and Smiti Sripathi",
year = "2018",
month = "11",
day = "1",
doi = "10.1177/8756479318799340",
language = "English",
volume = "34",
pages = "460--465",
journal = "Journal of Diagnostic Medical Sonography",
issn = "8756-4793",
publisher = "SAGE Publications Inc.",
number = "6",

}

Role of Shear Wave Elastography in the Assessment of Fibrosis in Chronic Liver Disease. / Bellamkonda, Sravya; Paruthikunnan, Samir M.; Kadavigere, Rajgopal V.; Sripathi, Smiti.

In: Journal of Diagnostic Medical Sonography, Vol. 34, No. 6, 01.11.2018, p. 460-465.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Role of Shear Wave Elastography in the Assessment of Fibrosis in Chronic Liver Disease

AU - Bellamkonda, Sravya

AU - Paruthikunnan, Samir M.

AU - Kadavigere, Rajgopal V.

AU - Sripathi, Smiti

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Objective: To evaluate the diagnostic performance of shear wave elastography in the estimation of fibrosis in patients with chronic liver disease by using biopsy and/or serum markers as reference standard. Materials and methods: 100 patients underwent point quantification-shear wave elastography, for whom noninvasive serum fibrosis indices like APRI, FIB-4, and King’s score were calculated. The receiver-operator characteristic (ROC) curve analysis was performed. Results: The shear wave elastography measurements showed moderate agreement with APRI, FIB-4, and fair agreement with King’s score. The AUROC for differentiating F0-F1, F2-F3, F2-F3, and F4 are 0.873 and 0.504 respectively using APRI as reference standard. The cutoff values derived for differentiating F0-F1 and F2-F3 was 7.07 and for differentiating F2-F3 and F4 was 11.94. Conclusion: The diagnostic performance of shear wave elastography is comparable with that of serum fibrosis indices APRI and FIB-4.

AB - Objective: To evaluate the diagnostic performance of shear wave elastography in the estimation of fibrosis in patients with chronic liver disease by using biopsy and/or serum markers as reference standard. Materials and methods: 100 patients underwent point quantification-shear wave elastography, for whom noninvasive serum fibrosis indices like APRI, FIB-4, and King’s score were calculated. The receiver-operator characteristic (ROC) curve analysis was performed. Results: The shear wave elastography measurements showed moderate agreement with APRI, FIB-4, and fair agreement with King’s score. The AUROC for differentiating F0-F1, F2-F3, F2-F3, and F4 are 0.873 and 0.504 respectively using APRI as reference standard. The cutoff values derived for differentiating F0-F1 and F2-F3 was 7.07 and for differentiating F2-F3 and F4 was 11.94. Conclusion: The diagnostic performance of shear wave elastography is comparable with that of serum fibrosis indices APRI and FIB-4.

UR - http://www.scopus.com/inward/record.url?scp=85056718032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056718032&partnerID=8YFLogxK

U2 - 10.1177/8756479318799340

DO - 10.1177/8756479318799340

M3 - Article

VL - 34

SP - 460

EP - 465

JO - Journal of Diagnostic Medical Sonography

JF - Journal of Diagnostic Medical Sonography

SN - 8756-4793

IS - 6

ER -