Role of Statins in New-onset Diabetes Mellitus: The Underlying Cause, Mechanisms Involved, and Strategies to Combat

Raghuvir Keni, Abinitha Sekhar, Karthik Gourishetti, Pawan G. Nayak, Manas Kinra, Nitesh Kumar, Rekha R. Shenoy, Anoop Kishore, Krishnadas Nandakumar

Research output: Contribution to journalArticlepeer-review

Abstract

Statins have transformed the treatment of cardiovascular diseases through primary and secondary prevention of events. Despite the success of statin's management of cardiovascular conditions, certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to induce diabetes. The risk further increases with intensive statin therapy or in patients with diabetes. A proper mechanism for the induction of the diabetic condition has not yet been determined. The involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance has been widely studied and established. The present review provides an update on the recent understanding of statin-induced diabetes. This covers the origin of statins, their development, possible mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to remedy the condition.

Original languageEnglish
Pages (from-to)1121-1128
Number of pages8
JournalCurrent Drug Targets
Volume22
Issue number10
DOIs
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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