Rosette-forming glioneuronal tumor - Evidence of stem cell origin with biphenotypic differentiation

S. Chakraborti, A. Mahadevan, A. Govindan, A. Bhateja, S. Dwarakanath, H. R. Aravinda, A. A. Phalguni, V. Santosh, T. C. Yasha, P. Rout, S. Sampath, S. K. Shankar

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Abstract

Rosette-forming glioneuronal tumor (RGNT) of the fourth ventricle is a new addition to the WHO classification of central nervous system tumors. To date, 72 cases have been described in literature. In the present study, we report the clinical and imaging features, with detailed histopathological and immunohistochemical profile, of eight cases. Confocal microscopic evidence of stem cell origin with biphenotypic, glial and neurocytic differentiation is presented with a comprehensive review of literature.

Original languageEnglish
Pages (from-to)581-588
Number of pages8
JournalVirchows Archiv
Volume461
Issue number5
DOIs
Publication statusPublished - 01-11-2012

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Chakraborti, S., Mahadevan, A., Govindan, A., Bhateja, A., Dwarakanath, S., Aravinda, H. R., ... Shankar, S. K. (2012). Rosette-forming glioneuronal tumor - Evidence of stem cell origin with biphenotypic differentiation. Virchows Archiv, 461(5), 581-588. https://doi.org/10.1007/s00428-012-1313-0