Rosin, a Polymer for Microencapsulation of Diltiazem Hydrochloride for Sustained Release by Emulsion - Solvent Evaporation Technique

M.N. Reddy, A.A. Shirwaikar

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Microcapsules of diltiazem hydrochloride with rosin were prepared by an emulsion-solvent-evaporation technique. Different amounts of drugs were added in order to obtain various drug to polymer ratios. The physical properties, loading efficiency and release rate depended on the drug to polymer ratio. The low drug content of microcapsules may be due to the interaction between the hydrochloride form of diltiazem and rosin in acetone, where as non-hydrochloride drug like sulphamethoxpyridazine showed complete loading efficiency. Span 80 was used to prevent aggregation. The mean size of the microcapsules decreased as the drug/polymer ratio increased. Since microcapsules were very small they were embedded into a tablet. The microcapsules produced a typical 24 h sustained release pattern. In vitro dissolution studies showed that first-order release characteristics were exhibited.
Original languageUndefined/Unknown
Pages (from-to)308-312
Number of pages5
JournalIndian Journal of Pharmaceutical Sciences
Volume62
Issue number4
Publication statusPublished - 2000

Cite this

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title = "Rosin, a Polymer for Microencapsulation of Diltiazem Hydrochloride for Sustained Release by Emulsion - Solvent Evaporation Technique",
abstract = "Microcapsules of diltiazem hydrochloride with rosin were prepared by an emulsion-solvent-evaporation technique. Different amounts of drugs were added in order to obtain various drug to polymer ratios. The physical properties, loading efficiency and release rate depended on the drug to polymer ratio. The low drug content of microcapsules may be due to the interaction between the hydrochloride form of diltiazem and rosin in acetone, where as non-hydrochloride drug like sulphamethoxpyridazine showed complete loading efficiency. Span 80 was used to prevent aggregation. The mean size of the microcapsules decreased as the drug/polymer ratio increased. Since microcapsules were very small they were embedded into a tablet. The microcapsules produced a typical 24 h sustained release pattern. In vitro dissolution studies showed that first-order release characteristics were exhibited.",
author = "M.N. Reddy and A.A. Shirwaikar",
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Rosin, a Polymer for Microencapsulation of Diltiazem Hydrochloride for Sustained Release by Emulsion - Solvent Evaporation Technique. / Reddy, M.N.; Shirwaikar, A.A.

In: Indian Journal of Pharmaceutical Sciences, Vol. 62, No. 4, 2000, p. 308-312.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rosin, a Polymer for Microencapsulation of Diltiazem Hydrochloride for Sustained Release by Emulsion - Solvent Evaporation Technique

AU - Reddy, M.N.

AU - Shirwaikar, A.A.

N1 - cited By 7

PY - 2000

Y1 - 2000

N2 - Microcapsules of diltiazem hydrochloride with rosin were prepared by an emulsion-solvent-evaporation technique. Different amounts of drugs were added in order to obtain various drug to polymer ratios. The physical properties, loading efficiency and release rate depended on the drug to polymer ratio. The low drug content of microcapsules may be due to the interaction between the hydrochloride form of diltiazem and rosin in acetone, where as non-hydrochloride drug like sulphamethoxpyridazine showed complete loading efficiency. Span 80 was used to prevent aggregation. The mean size of the microcapsules decreased as the drug/polymer ratio increased. Since microcapsules were very small they were embedded into a tablet. The microcapsules produced a typical 24 h sustained release pattern. In vitro dissolution studies showed that first-order release characteristics were exhibited.

AB - Microcapsules of diltiazem hydrochloride with rosin were prepared by an emulsion-solvent-evaporation technique. Different amounts of drugs were added in order to obtain various drug to polymer ratios. The physical properties, loading efficiency and release rate depended on the drug to polymer ratio. The low drug content of microcapsules may be due to the interaction between the hydrochloride form of diltiazem and rosin in acetone, where as non-hydrochloride drug like sulphamethoxpyridazine showed complete loading efficiency. Span 80 was used to prevent aggregation. The mean size of the microcapsules decreased as the drug/polymer ratio increased. Since microcapsules were very small they were embedded into a tablet. The microcapsules produced a typical 24 h sustained release pattern. In vitro dissolution studies showed that first-order release characteristics were exhibited.

M3 - Article

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SP - 308

EP - 312

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

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