Rotavirus associated acute gastroenteritis among under-five children admitted in two secondary care hospitals in southern Karnataka, India

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Abstract

Background Rotavirus infection is the common cause of severe diarrhea among under-five children. Globally it is responsible for majority of the hospital visits and admissions due to diarrhea in this age group. This hospital-based surveillance aimed to assess the burden of rotavirus diarrhea and to identify its prevalent strains among under-five children. Methods The study was conducted in two secondary level health care facilities of Manipal University, Manipal during November 2011 through July 2012. All under-five children admitted with acute diarrhea were recruited into the study. Results A total of 95 children were admitted with acute diarrhea during the study period. Of the 95 stool samples collected, 14 were inadequate and 81 samples were tested for the presence of rotavirus using commercial enzyme immunoassay kit (Premier Rotaclone Qualitative ELISA). Rotavirus positive samples were shipped to Central laboratory at CMC, Vellore for strain surveillance and characterization. Out of the 81 stool samples tested for rotavirus, 31 samples (38.3%) were positive for rotavirus VP6 antigen. Rota positivity was observed to be highest during the month of December (29.0%) and lowest in the month of June. Majority of the rotavirus positive cases (45.2%) were among children aged 13–24 months and among those who had very severe diarrhea (56.5%). The most common genotypes identified were G1P[8] and G2P[4] strains (25.8% each). Conclusions Though the burden of overall diarrhea among under-five children is not very high in this area, the proportion of rotavirus diarrhea among the hospitalized children is considerably high.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalClinical Epidemiology and Global Health
Volume5
Issue number1
DOIs
Publication statusPublished - 01-03-2017

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Secondary Care
Rotavirus
Gastroenteritis
India
Diarrhea
Rotavirus Infections
Hospitalized Child
Health Facilities
Immunoenzyme Techniques
Health Status
Age Groups
Enzyme-Linked Immunosorbent Assay
Genotype
Delivery of Health Care
Antigens

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{465aa5ede3b44aaba76c328ff8bfa748,
title = "Rotavirus associated acute gastroenteritis among under-five children admitted in two secondary care hospitals in southern Karnataka, India",
abstract = "Background Rotavirus infection is the common cause of severe diarrhea among under-five children. Globally it is responsible for majority of the hospital visits and admissions due to diarrhea in this age group. This hospital-based surveillance aimed to assess the burden of rotavirus diarrhea and to identify its prevalent strains among under-five children. Methods The study was conducted in two secondary level health care facilities of Manipal University, Manipal during November 2011 through July 2012. All under-five children admitted with acute diarrhea were recruited into the study. Results A total of 95 children were admitted with acute diarrhea during the study period. Of the 95 stool samples collected, 14 were inadequate and 81 samples were tested for the presence of rotavirus using commercial enzyme immunoassay kit (Premier Rotaclone Qualitative ELISA). Rotavirus positive samples were shipped to Central laboratory at CMC, Vellore for strain surveillance and characterization. Out of the 81 stool samples tested for rotavirus, 31 samples (38.3{\%}) were positive for rotavirus VP6 antigen. Rota positivity was observed to be highest during the month of December (29.0{\%}) and lowest in the month of June. Majority of the rotavirus positive cases (45.2{\%}) were among children aged 13–24 months and among those who had very severe diarrhea (56.5{\%}). The most common genotypes identified were G1P[8] and G2P[4] strains (25.8{\%} each). Conclusions Though the burden of overall diarrhea among under-five children is not very high in this area, the proportion of rotavirus diarrhea among the hospitalized children is considerably high.",
author = "Shetty, {Ranjitha S.} and Kamath, {Veena G.} and Nayak, {Dinesh M.} and Asha Hegde and Tarun Saluja",
year = "2017",
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language = "English",
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journal = "Clinical Epidemiology and Global Health",
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TY - JOUR

T1 - Rotavirus associated acute gastroenteritis among under-five children admitted in two secondary care hospitals in southern Karnataka, India

AU - Shetty, Ranjitha S.

AU - Kamath, Veena G.

AU - Nayak, Dinesh M.

AU - Hegde, Asha

AU - Saluja, Tarun

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background Rotavirus infection is the common cause of severe diarrhea among under-five children. Globally it is responsible for majority of the hospital visits and admissions due to diarrhea in this age group. This hospital-based surveillance aimed to assess the burden of rotavirus diarrhea and to identify its prevalent strains among under-five children. Methods The study was conducted in two secondary level health care facilities of Manipal University, Manipal during November 2011 through July 2012. All under-five children admitted with acute diarrhea were recruited into the study. Results A total of 95 children were admitted with acute diarrhea during the study period. Of the 95 stool samples collected, 14 were inadequate and 81 samples were tested for the presence of rotavirus using commercial enzyme immunoassay kit (Premier Rotaclone Qualitative ELISA). Rotavirus positive samples were shipped to Central laboratory at CMC, Vellore for strain surveillance and characterization. Out of the 81 stool samples tested for rotavirus, 31 samples (38.3%) were positive for rotavirus VP6 antigen. Rota positivity was observed to be highest during the month of December (29.0%) and lowest in the month of June. Majority of the rotavirus positive cases (45.2%) were among children aged 13–24 months and among those who had very severe diarrhea (56.5%). The most common genotypes identified were G1P[8] and G2P[4] strains (25.8% each). Conclusions Though the burden of overall diarrhea among under-five children is not very high in this area, the proportion of rotavirus diarrhea among the hospitalized children is considerably high.

AB - Background Rotavirus infection is the common cause of severe diarrhea among under-five children. Globally it is responsible for majority of the hospital visits and admissions due to diarrhea in this age group. This hospital-based surveillance aimed to assess the burden of rotavirus diarrhea and to identify its prevalent strains among under-five children. Methods The study was conducted in two secondary level health care facilities of Manipal University, Manipal during November 2011 through July 2012. All under-five children admitted with acute diarrhea were recruited into the study. Results A total of 95 children were admitted with acute diarrhea during the study period. Of the 95 stool samples collected, 14 were inadequate and 81 samples were tested for the presence of rotavirus using commercial enzyme immunoassay kit (Premier Rotaclone Qualitative ELISA). Rotavirus positive samples were shipped to Central laboratory at CMC, Vellore for strain surveillance and characterization. Out of the 81 stool samples tested for rotavirus, 31 samples (38.3%) were positive for rotavirus VP6 antigen. Rota positivity was observed to be highest during the month of December (29.0%) and lowest in the month of June. Majority of the rotavirus positive cases (45.2%) were among children aged 13–24 months and among those who had very severe diarrhea (56.5%). The most common genotypes identified were G1P[8] and G2P[4] strains (25.8% each). Conclusions Though the burden of overall diarrhea among under-five children is not very high in this area, the proportion of rotavirus diarrhea among the hospitalized children is considerably high.

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JF - Clinical Epidemiology and Global Health

SN - 2213-3984

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