TY - JOUR
T1 - Rutin a citrus flavonoid attenuates sodium arsenate induced cytotoxicity in CHO cells
AU - Salmataj, S. A.
AU - Bhat, Pushpanjali
AU - Kamath, Shobha
N1 - Publisher Copyright:
© 2020 Informatics Publishing Limited and The Society of Toxicology. All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured
AB - The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured
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U2 - 10.18311/ti/2020/v27i3&4/26077
DO - 10.18311/ti/2020/v27i3&4/26077
M3 - Article
AN - SCOPUS:85109539169
SN - 0971-6580
VL - 27
SP - 188
EP - 192
JO - Toxicology International
JF - Toxicology International
IS - 3
ER -
