Rutin a citrus flavonoid attenuates sodium arsenate induced cytotoxicity in CHO cells

S. A. Salmataj, Pushpanjali Bhat, Shobha Kamath

Research output: Contribution to journalArticlepeer-review

Abstract

The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured

Original languageEnglish
Pages (from-to)188-192
Number of pages5
JournalToxicology International
Volume27
Issue number3
DOIs
Publication statusPublished - 07-2020

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

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