Abstract
Nicotinamide, a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. Consequently the aim of the present study was to investigate the safety profile of Nicotinamide gel 2%, 3% and 4% (Apex Laboratories Private Limited, Chennai, India on skin of normal healthy New Zealand White Albino rabbits. The safety assessment was done for the single dose topical application of Nicotinamide 2%, 3% and 4% gel by the Draize skin test method in New Zealand White Albino rabbits. The topical application of Nicotinamide gel did not cause any erythema and edema in the skin of New Zealand White Albino rabbits like the control group. The primary irritation index was found to be zero which indicates the non-irritant nature of Nicotinamide 2%, 3% and 4% gel. Further, clinical evaluation has to be performed to precisely define the long term dermal safety of Nicotinamide gel 2%, 3% and 4% of human subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 815-817 |
| Number of pages | 3 |
| Journal | Research Journal of Pharmaceutical, Biological and Chemical Sciences |
| Volume | 5 |
| Issue number | 6 |
| Publication status | Published - 2014 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Safety assessment of topical formulation of nicotinamide gel (2%), (3%) and (4%) on skin of normal healthy New Zealand white Albino rabbits. / Satyam, S. M.; Bairy, K. L.; Musharraf, S.; Fernandes, D. L.
In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 5, No. 6, 2014, p. 815-817.Research output: Contribution to journal › Article
TY - JOUR
T1 - Safety assessment of topical formulation of nicotinamide gel (2%), (3%) and (4%) on skin of normal healthy New Zealand white Albino rabbits
AU - Satyam, S. M.
AU - Bairy, K. L.
AU - Musharraf, S.
AU - Fernandes, D. L.
PY - 2014
Y1 - 2014
N2 - Nicotinamide, a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. Consequently the aim of the present study was to investigate the safety profile of Nicotinamide gel 2%, 3% and 4% (Apex Laboratories Private Limited, Chennai, India on skin of normal healthy New Zealand White Albino rabbits. The safety assessment was done for the single dose topical application of Nicotinamide 2%, 3% and 4% gel by the Draize skin test method in New Zealand White Albino rabbits. The topical application of Nicotinamide gel did not cause any erythema and edema in the skin of New Zealand White Albino rabbits like the control group. The primary irritation index was found to be zero which indicates the non-irritant nature of Nicotinamide 2%, 3% and 4% gel. Further, clinical evaluation has to be performed to precisely define the long term dermal safety of Nicotinamide gel 2%, 3% and 4% of human subjects.
AB - Nicotinamide, a physiologically active form of niacin (nicotinic acid), in combination with zinc is being assessed in clinical studies for the treatment of inflammatory skin diseases such as acne vulgaris and bullous pemphigoid. Consequently the aim of the present study was to investigate the safety profile of Nicotinamide gel 2%, 3% and 4% (Apex Laboratories Private Limited, Chennai, India on skin of normal healthy New Zealand White Albino rabbits. The safety assessment was done for the single dose topical application of Nicotinamide 2%, 3% and 4% gel by the Draize skin test method in New Zealand White Albino rabbits. The topical application of Nicotinamide gel did not cause any erythema and edema in the skin of New Zealand White Albino rabbits like the control group. The primary irritation index was found to be zero which indicates the non-irritant nature of Nicotinamide 2%, 3% and 4% gel. Further, clinical evaluation has to be performed to precisely define the long term dermal safety of Nicotinamide gel 2%, 3% and 4% of human subjects.
UR - http://www.scopus.com/inward/record.url?scp=84911119631&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911119631&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84911119631
VL - 5
SP - 815
EP - 817
JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences
JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences
SN - 0975-8585
IS - 6
ER -