Salivary flow rate in patients with schizophrenia on clozapine

Samir Kumar Praharaj, Amlan Kusum Jana, Kausik Goswami, Poonam R. Das, Nishant Goyal, Vinod Kumar Sinha

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Aims: To assess the change in salivary flow rate in patients with schizophrenia on clozapine and whether the change in salivary flow rate was dose related. Methods: Twenty male inpatients with a diagnosis of schizophrenia according to the International Statistical Classification of Diseases, 10th Revision diagnostic criteria for research who were started on clozapine were recruited for the study. Unstimulated salivary flow rate was assessed at baseline and then weekly for 4 weeks using cotton swab method in 17 patients. Results: Repeated-measures analysis of variance showed a significant increase in salivary flow rate over time (F [2.37/37.94] = 3.134, P = 0.047, Greenhouse-Geisser correction, η = 0.16). Also, there was a significant increase in salivary flow rate between weeks 2 and 3 (P < 0.05). There was no correlation between salivary flow rate and mean clozapine dose. Conclusions: There was a significant increase in salivary flow rate from baseline after starting clozapine, with a significant increase from the second to the third week followed by a "plateau.".

Original languageEnglish
Pages (from-to)176-178
Number of pages3
JournalClinical Neuropharmacology
Volume33
Issue number4
DOIs
Publication statusPublished - 01-07-2010

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Clozapine
Schizophrenia
International Classification of Diseases
Inpatients
Analysis of Variance
Research

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

Cite this

Praharaj, Samir Kumar ; Jana, Amlan Kusum ; Goswami, Kausik ; Das, Poonam R. ; Goyal, Nishant ; Sinha, Vinod Kumar. / Salivary flow rate in patients with schizophrenia on clozapine. In: Clinical Neuropharmacology. 2010 ; Vol. 33, No. 4. pp. 176-178.
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Salivary flow rate in patients with schizophrenia on clozapine. / Praharaj, Samir Kumar; Jana, Amlan Kusum; Goswami, Kausik; Das, Poonam R.; Goyal, Nishant; Sinha, Vinod Kumar.

In: Clinical Neuropharmacology, Vol. 33, No. 4, 01.07.2010, p. 176-178.

Research output: Contribution to journalArticle

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