TY - JOUR
T1 - Salivary flow rate in patients with schizophrenia on clozapine
AU - Praharaj, Samir Kumar
AU - Jana, Amlan Kusum
AU - Goswami, Kausik
AU - Das, Poonam R.
AU - Goyal, Nishant
AU - Sinha, Vinod Kumar
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Aims: To assess the change in salivary flow rate in patients with schizophrenia on clozapine and whether the change in salivary flow rate was dose related. Methods: Twenty male inpatients with a diagnosis of schizophrenia according to the International Statistical Classification of Diseases, 10th Revision diagnostic criteria for research who were started on clozapine were recruited for the study. Unstimulated salivary flow rate was assessed at baseline and then weekly for 4 weeks using cotton swab method in 17 patients. Results: Repeated-measures analysis of variance showed a significant increase in salivary flow rate over time (F [2.37/37.94] = 3.134, P = 0.047, Greenhouse-Geisser correction, η = 0.16). Also, there was a significant increase in salivary flow rate between weeks 2 and 3 (P < 0.05). There was no correlation between salivary flow rate and mean clozapine dose. Conclusions: There was a significant increase in salivary flow rate from baseline after starting clozapine, with a significant increase from the second to the third week followed by a "plateau.".
AB - Aims: To assess the change in salivary flow rate in patients with schizophrenia on clozapine and whether the change in salivary flow rate was dose related. Methods: Twenty male inpatients with a diagnosis of schizophrenia according to the International Statistical Classification of Diseases, 10th Revision diagnostic criteria for research who were started on clozapine were recruited for the study. Unstimulated salivary flow rate was assessed at baseline and then weekly for 4 weeks using cotton swab method in 17 patients. Results: Repeated-measures analysis of variance showed a significant increase in salivary flow rate over time (F [2.37/37.94] = 3.134, P = 0.047, Greenhouse-Geisser correction, η = 0.16). Also, there was a significant increase in salivary flow rate between weeks 2 and 3 (P < 0.05). There was no correlation between salivary flow rate and mean clozapine dose. Conclusions: There was a significant increase in salivary flow rate from baseline after starting clozapine, with a significant increase from the second to the third week followed by a "plateau.".
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U2 - 10.1097/WNF.0b013e3181e204e0
DO - 10.1097/WNF.0b013e3181e204e0
M3 - Article
C2 - 20661023
AN - SCOPUS:77955145008
SN - 0362-5664
VL - 33
SP - 176
EP - 178
JO - Clinical Neuropharmacology
JF - Clinical Neuropharmacology
IS - 4
ER -